Detailed information of TA system TA206623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_31(antitoxin)
• Location: 3029194..3030425
• Replicon: chromosome
• Accession: NZ_CP077073
• Organism: Pseudomonas muyukensis strain COW39

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KSS95_RS13805
• Protein ID: WP_217847637.1
• Coordinates: 3029194..3029781 (-)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KSS95_RS13810
• Protein ID: WP_217847638.1
• Coordinates: 3029862..3030425 (-)
• Length: 188 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS95_RS13780 (KSS95_13780)	3024574..3025254	-	681	WP_217847633.1	response regulator transcription factor	-
KSS95_RS13785 (KSS95_13785)	3025414..3026433	-	1020	WP_217847634.1	branched-chain amino acid aminotransferase	-
KSS95_RS13790 (KSS95_13790)	3026557..3028137	-	1581	WP_217847635.1	ATP-binding cassette domain-containing protein	-
KSS95_RS13795 (KSS95_13795)	3028470..3028823	-	354	WP_217853985.1	hypothetical protein	-
KSS95_RS13800 (KSS95_13800)	3028820..3029185	-	366	WP_217847636.1	glyoxalase superfamily protein	-
KSS95_RS13805 (KSS95_13805)	3029194..3029781	-	588	WP_217847637.1	HD domain-containing protein	Toxin
KSS95_RS13810 (KSS95_13810)	3029862..3030425	-	564	WP_217847638.1	helix-turn-helix transcriptional regulator	Antitoxin
KSS95_RS13815 (KSS95_13815)	3030661..3031494	+	834	WP_217847639.1	urease accessory protein UreD	-
KSS95_RS13820 (KSS95_13820)	3031505..3031807	+	303	WP_217847640.1	urease subunit gamma	-
KSS95_RS13825 (KSS95_13825)	3031818..3032135	+	318	WP_217853986.1	urease subunit beta	-
KSS95_RS13830 (KSS95_13830)	3032132..3033835	+	1704	WP_217847641.1	urease subunit alpha	-
KSS95_RS13835 (KSS95_13835)	3033889..3034362	+	474	WP_217847642.1	urease accessory protein UreE	-
KSS95_RS13840 (KSS95_13840)	3034378..3034923	+	546	WP_217847643.1	HupE/UreJ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21950.88 Da
• Isoelectric Point: 5.2796

>T206623 WP_217847637.1 NZ_CP077073:c3029781-3029194 [Pseudomonas muyukensis]
MNHQLLANRLAFLREAERLKDVLRSAHTATGRTESTAEHSWRLCLMALVFADQMPGLDLLKVVQLCVIHDLGEALHGDIP
AVAQHPGQDKDQQEFADLRQLCAVLDEPLRTGILDLWQEYTAARSAEALAVKALDKLETLLQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFQALREQIDEQTRKRMTAPQPPANQ

Nucleotide

• Length: 588 bp

>T206623 NZ_CP102514:4754150-4754404 [Streptomyces yangpuensis]
GTGAGGCTTGTCTTTGAGGATCAGGGCTGGGAGGACTACACGTCCGGGCTCAAGAGCGACCGCAAGATGCTCGCCCGGAT
CAACAAGCTCATCGAGGACGTCAGACGTGACCCGTTCTCAGGGATCGGCAAGCCCGAACCTTTGAAATACCACCTGCCCG
GCGCGTGGTCGCGGCGGATCGACGACGAGCATCGCCTCGTCTACCTGGTGACGGAGAAAGAGATCATCATCCTTGCGGCT
CGGTACCACTACTGA

Antitoxin

Protein

• Length: 188 a.a.
• Molecular weight: 20504.66 Da
• Isoelectric Point: 11.7392

>AT206623 WP_217847638.1 NZ_CP077073:c3030425-3029862 [Pseudomonas muyukensis]
MPATALPQPAGLGIALRRWRLLHRVKQAHAAQLFGVAQSTISRWENGQQLMSPQEQARLGQLLGARLSAAADQALARLVE
GNQRPVHLVCDLSHRLLACSPSRAAEFALPLSDLLGRSLWRFSSEAIMQREASLQALGWREQLAPPALEFDTGHNRSRVV
PITAGRCRWTRLLLADGSAARLVETLA

Nucleotide

• Length: 564 bp

>AT206623 NZ_CP102514:4753872-4754153 [Streptomyces yangpuensis]
ATGTCCATAACCGCCAGCGAAGCCCGCAGGGAACTCTTTCCGCTGATCAAGAAGGTCAACGAGAACCACGAGGCCATCGA
GATCGTCTCGAAGCACGGCAACGCCGTGCTCGTCTCGGCCGAGGACTACGCGGCCCTGCGTGAGGGGTCGTACCTGCTGC
GCTCTCCGGTGAACGCCCGCCGGCTGCTCAAGGCGTACGAGAACGCCCTGGCAAACATCAATGTGTCGGAGCGCGAGCTG
ATCGATCCGGACTCGGCGGACGCGGGTGCCGGTGCCGCGTGA