Detailed information of TA system TA020662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1883..2489
• Replicon: chromosome
• Accession: NC_003106
• Organism: Sulfolobus tokodaii str. 7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: STK_RS00015
• Protein ID: WP_084742605.1
• Coordinates: 1883..2272 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: STK_RS00020
• Protein ID: WP_052846112.1
• Coordinates: 2268..2489 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STK_RS00005 (STK_00005)	151..396	-	246	WP_052846110.1	hypothetical protein	-
STK_RS00010 (ST0001)	526..1632	-	1107	WP_010977924.1	hypothetical protein	-
STK_RS00015 (STK_00012)	1883..2272	-	390	WP_084742605.1	type II toxin-antitoxin system VapC family toxin	Toxin
STK_RS00020 (STK_00014)	2268..2489	-	222	WP_052846112.1	hypothetical protein	Antitoxin
STK_RS00025 (STK_00016)	2722..2937	-	216	WP_010977928.1	hypothetical protein	-
STK_RS15485 (STK_00018)	3247..3399	-	153	WP_010977930.1	HEPN domain-containing protein	-
STK_RS00035 (ST0002)	3744..5483	+	1740	WP_010977931.1	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (1-122)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14671.29 Da
• Isoelectric Point: 8.3584

>T20662 WP_084742605.1 NC_003106:c2272-1883 [Sulfurisphaera tokodaii str. 7]
IDASVLAKFVTKEKGWEKITEILKDAETLDFALVEVSNVVWKKVVLTRELTEQDAIKAVTIIKEYLPQLLTLNKSVNLIE
RAMEISVKEKIPIYDSLYIALAERKGSKLVTGDKKQHEIAKKYVISELI

Nucleotide

• Length: 390 bp

>T20662 NC_003106:c2272-1883 [Sulfurisphaera tokodaii str. 7]
ATTGACGCATCTGTTTTAGCTAAGTTTGTAACTAAGGAGAAAGGGTGGGAGAAGATTACGGAAATTCTGAAAGACGCTGA
GACGTTGGACTTTGCGTTGGTGGAAGTATCTAACGTAGTGTGGAAGAAAGTTGTATTAACCAGAGAGTTAACTGAACAAG
ACGCGATTAAGGCGGTTACTATTATCAAAGAATATTTGCCACAGTTGCTGACATTGAATAAAAGCGTTAACTTAATTGAA
AGGGCTATGGAGATTTCCGTAAAAGAGAAAATCCCAATATATGATTCACTTTATATCGCACTGGCTGAACGTAAAGGGAG
TAAATTAGTAACTGGAGATAAGAAGCAACATGAGATAGCAAAGAAGTATGTCATCTCAGAGCTTATATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 9001.22 Da
• Isoelectric Point: 4.7802

>AT20662 WP_052846112.1 NC_003106:c2489-2268 [Sulfurisphaera tokodaii str. 7]
MKTVYSLRIDKELREEMEKYNIKWNEEIENFIRRRIEELKKEEILKKINEILQTMPETNSSSAELVREDRDNN

Nucleotide

• Length: 222 bp

>AT20662 NC_003106:c2489-2268 [Sulfurisphaera tokodaii str. 7]
ATGAAGACCGTATACAGTTTAAGGATAGATAAAGAGTTACGTGAGGAGATGGAGAAATACAATATTAAATGGAATGAGGA
GATTGAGAACTTTATTAGGAGGAGGATTGAGGAGTTAAAGAAAGAAGAGATCTTAAAGAAGATTAATGAAATTCTCCAAA
CAATGCCAGAAACTAACTCTAGTAGTGCGGAATTGGTGAGGGAAGATAGGGATAATAATTGA