Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 347311..347933 Replicon chromosome
Accession NZ_CP077073
Organism Pseudomonas muyukensis strain COW39

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS95_RS01680 Protein ID WP_134693260.1
Coordinates 347742..347933 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS95_RS01675 Protein ID WP_217851059.1
Coordinates 347311..347724 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS95_RS24515 342564..342821 + 258 WP_225935552.1 DUF3079 domain-containing protein -
KSS95_RS01660 (KSS95_01660) 342773..345067 - 2295 WP_217851053.1 TonB-dependent siderophore receptor -
KSS95_RS01665 (KSS95_01665) 345210..345929 + 720 WP_217851055.1 response regulator transcription factor -
KSS95_RS01670 (KSS95_01670) 345931..347310 + 1380 WP_217851057.1 ATP-binding protein -
KSS95_RS01675 (KSS95_01675) 347311..347724 - 414 WP_217851059.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS95_RS01680 (KSS95_01680) 347742..347933 - 192 WP_134693260.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS95_RS01685 (KSS95_01685) 348113..348538 - 426 WP_217851061.1 hypothetical protein -
KSS95_RS01690 (KSS95_01690) 348535..349395 - 861 WP_217853917.1 type III secretion system translocon subunit SctE -
KSS95_RS01695 (KSS95_01695) 349694..350620 - 927 WP_217851062.1 type VI secretion system-associated lipoprotein TagQ -
KSS95_RS01700 (KSS95_01700) 350699..352465 - 1767 WP_217851064.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7089.28 Da        Isoelectric Point: 10.1618

>T206618 WP_134693260.1 NZ_CP077073:c347933-347742 [Pseudomonas muyukensis]
MNSREMISVIEADGWYLVRCKGSHHHFKHPDKPGLVTIPHPKKDLLPATAASILRQARIVYAS

Download         Length: 192 bp

>T206618 NZ_CP102512:c5133215-5132934 [Streptomyces sp. CA-210063]
ATGGGGTACGTCACGCGCTTCACGCCGCACGCTCAACGGGACATGCTCAAGGTCCCGCGTCCGGACGCCCTGCGCATCCT
GTACCGCCTCACCGAACTCCAGAAGGCGATGGACGCGGGGGACACCGCGTCGTTCGACCTCAAGGCCCTCCAAGGGCACA
GTGCCCGCTGGCGGCTCAGCATCGGCGACTACCGGCTTGTCCACACCGTAGAGGACGGCCAGTTGATCGTGTGGGTCCTG
GCTGTTGGCAATCGTCGCGACATCTACCGCCAAGTTCCGTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14947.07 Da        Isoelectric Point: 4.5918

>AT206618 WP_217851059.1 NZ_CP077073:c347724-347311 [Pseudomonas muyukensis]
MLFPIAILPGDDQYAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPKASKVTAHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALKILQGECK

Download         Length: 414 bp

>AT206618 NZ_CP102512:c5133501-5133220 [Streptomyces sp. CA-210063]
ATGAGTGATCCAGTCGTCGAATCCATGGCCGAGGTCCGCAGTCACCTCGCCGACGTCATCGATCGCGCTCGTCGGGAGGA
AACCCCGACGATCATCACTCGGCGCGGCAAACAGGAAGCCGTCGTGATCGACATCCAGGAGTACCAACGCCTGCGTGAGA
TCGCGGAGAACGCCGAAGAGGCATGGCTCAACCAGCTGGCCGACGAAGCCGAGTCCGAGGGCACGGAGGGCTCCGTCTCG
CTCGAAGAGATGGCCGCCTTGCTGCGCGCTCATCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References