Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4535371..4535985 Replicon chromosome
Accession NZ_CP077072
Organism Luteibacter anthropi strain SM7.4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KR767_RS19130 Protein ID WP_250877453.1
Coordinates 4535371..4535550 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KR767_RS19135 Protein ID WP_166949152.1
Coordinates 4535584..4535985 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KR767_RS19105 (KR767_19090) 4531775..4532062 + 288 WP_250877449.1 hypothetical protein -
KR767_RS19110 (KR767_19095) 4532152..4533618 - 1467 WP_250877450.1 alpha-L-fucosidase -
KR767_RS19115 (KR767_19100) 4533711..4534061 - 351 WP_166949158.1 metalloregulator ArsR/SmtB family transcription factor -
KR767_RS19120 (KR767_19105) 4534140..4534886 + 747 WP_250877451.1 arsenical resistance protein ArsH -
KR767_RS19125 (KR767_19110) 4534883..4535290 + 408 WP_250877452.1 arsenate reductase (glutaredoxin) -
KR767_RS19130 (KR767_19115) 4535371..4535550 + 180 WP_250877453.1 type II toxin-antitoxin system HicA family toxin Toxin
KR767_RS19135 (KR767_19120) 4535584..4535985 + 402 WP_166949152.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KR767_RS19140 (KR767_19125) 4536292..4539198 + 2907 WP_166949150.1 TonB-dependent receptor -
KR767_RS19145 (KR767_19130) 4539237..4540439 + 1203 WP_250877454.1 glycoside hydrolase family 27 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6223.36 Da        Isoelectric Point: 11.7056

>T206617 WP_250877453.1 NZ_CP077072:4535371-4535550 [Luteibacter anthropi]
MNSADLVRLLRAHGFCLVSIRGSHHKLQNASGVTVIAPHPRKDLGKGLVAAIKKQAGIA

Download         Length: 180 bp

>T206617 NZ_CP102509:5403551-5403922 [Streptomyces sp. NBC_00162]
GTGACCCACTACCTGACCCTGCCCGAGGTGCTGAACCTCGCGGAGCGGCTCGGGACCAGCGAGGTGCGTGACTACGGGCT
GCTCGACTCGGCGCTGGCGCGCCCCCAGTCGAGCGTGTTCGGTCAGGACGCCTACCCGGACATCTGGGAAAAGGCTGCAG
CCCTGATGGAATCGCTCGCCCGCAACCACGGGCTGGTGGACGGCAACAAGCGGATCGCCTGGTACGCGACCTGGGTCTTC
CTGCACATGAACGGCCACCCCCTGGACGCCGACTTCGACGTCGACGAGGCCGAGCGCTTCGTGCTGGACGTATGTCAGGG
CTCGCTGGACGTACCCAAGATCGCAGCGCAGCTGCCGAAGTTCGCCCGGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14186.05 Da        Isoelectric Point: 4.2698

>AT206617 WP_166949152.1 NZ_CP077072:4535584-4535985 [Luteibacter anthropi]
MRYPIAIEPGTDGSAYGVIVPDLPGCFSAGNTLDEAVANAEEAILLFLEDAIEEGTMPPAASTLEALRSRADFSGWTWAL
ANVDLAKLSTKAVRVNITVPDRLLTAIDSYAERHGETRSGFLTRAAMEAMRAA

Download         Length: 402 bp

>AT206617 NZ_CP102509:5403357-5403554 [Streptomyces sp. NBC_00162]
ATGGCTGGTCTCAACGTCAGGTTCACCGAAGAAGAGCTGGACGCCCTGCGCGAGCGCGCCGAGGCGGAGGGCCGCAGCAT
GCAGTCCTTCGCGCACGAGGCGGTGATCAGGGCCATAAACGAACACTCCCGGCTGTTCAACGAAGCGGCCGAGCACGTCC
TGAAGGTCAGCGGTGAGCTGAACCGGAGGCTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References