Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 77004..77582 | Replicon | chromosome |
| Accession | NZ_CP077061 | ||
| Organism | Vibrio cholerae strain MS84A | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | J3992_RS14310 | Protein ID | WP_001180243.1 |
| Coordinates | 77265..77582 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | J3992_RS14305 | Protein ID | WP_000557292.1 |
| Coordinates | 77004..77246 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3992_RS14255 (J3992_14240) | 72398..72844 | - | 447 | WP_000006157.1 | hypothetical protein | - |
| J3992_RS14260 (J3992_14245) | 73094..73219 | - | 126 | WP_001900195.1 | DUF645 family protein | - |
| J3992_RS14265 (J3992_14250) | 73612..73884 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| J3992_RS14270 (J3992_14255) | 73881..74378 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| J3992_RS14275 (J3992_14260) | 74395..74463 | - | 69 | Protein_155 | acetyltransferase | - |
| J3992_RS14280 (J3992_14265) | 74528..74989 | - | 462 | WP_001903091.1 | lipocalin family protein | - |
| J3992_RS14285 (J3992_14270) | 75180..75716 | - | 537 | WP_000469482.1 | GNAT family protein | - |
| J3992_RS14290 (J3992_14275) | 75974..76195 | - | 222 | WP_032467793.1 | DUF1289 domain-containing protein | - |
| J3992_RS14295 (J3992_14280) | 76204..76317 | - | 114 | WP_001900214.1 | hypothetical protein | - |
| J3992_RS14300 (J3992_14285) | 76374..76760 | - | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| J3992_RS14305 (J3992_14290) | 77004..77246 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J3992_RS14310 (J3992_14295) | 77265..77582 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J3992_RS14315 (J3992_14300) | 77736..78074 | - | 339 | WP_000713853.1 | hypothetical protein | - |
| J3992_RS14320 (J3992_14305) | 78232..78936 | - | 705 | WP_000087610.1 | HNH endonuclease | - |
| J3992_RS14325 (J3992_14310) | 79098..80306 | - | 1209 | WP_000272282.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| J3992_RS14330 (J3992_14315) | 80468..81145 | - | 678 | WP_000254617.1 | HNH endonuclease signature motif containing protein | - |
| J3992_RS14335 (J3992_14320) | 81340..81522 | - | 183 | WP_000923153.1 | DUF645 family protein | - |
| J3992_RS14340 (J3992_14325) | 81694..81756 | - | 63 | Protein_168 | acetyltransferase | - |
| J3992_RS14345 (J3992_14330) | 81876..82058 | - | 183 | WP_000923340.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 1..1044173 | 1044172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T206613 WP_001180243.1 NZ_CP077061:77265-77582 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T206613 NZ_CP102502:46422-46952 [Citrobacter youngae]
ATGGAGGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGGCAGCATAACAGTAAGATCTTACGTGGTTATGTTCTCGTGACGAGAGAGG
ATAAACCGCGTGTGATGGGGTACTACACGCTATCAGGAAGTTGCTTTGAGAAAATACTTCTACCCAGCAAAACACAACAA
AAGCGTGTACCCTACAAGAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCACCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGACTGGGTTTCATTCAGTTAAAGGAAGAAAACTGTAACTCGCTC
TTTTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA
ATGGAGGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGGCAGCATAACAGTAAGATCTTACGTGGTTATGTTCTCGTGACGAGAGAGG
ATAAACCGCGTGTGATGGGGTACTACACGCTATCAGGAAGTTGCTTTGAGAAAATACTTCTACCCAGCAAAACACAACAA
AAGCGTGTACCCTACAAGAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCACCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGACTGGGTTTCATTCAGTTAAAGGAAGAAAACTGTAACTCGCTC
TTTTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT206613 WP_000557292.1 NZ_CP077061:77004-77246 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT206613 NZ_CP102502:46149-46418 [Citrobacter youngae]
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCTTGGAACCTGGTTATGGATGCAATCATTAATCCGCCAGCACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCTTGGAACCTGGTTATGGATGCAATCATTAATCCGCCAGCACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |