206612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 73612..74378 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag J3992_RS14270 Protein ID WP_000982260.1
Coordinates 73881..74378 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag J3992_RS14265 Protein ID WP_000246253.1
Coordinates 73612..73884 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS14205 (J3992_14190) 69109..69351 - 243 WP_000107461.1 hypothetical protein -
J3992_RS14210 (J3992_14195) 69443..69592 - 150 WP_071908333.1 DUF3265 domain-containing protein -
J3992_RS14215 (J3992_14200) 69565..69816 - 252 WP_001890111.1 TIGR03643 family protein -
J3992_RS14220 (J3992_14205) 70011..70397 - 387 WP_000703163.1 VOC family protein -
J3992_RS14225 (J3992_14210) 70387..70488 - 102 WP_001921603.1 hypothetical protein -
J3992_RS14230 (J3992_14215) 70688..70786 - 99 WP_223225486.1 DUF3709 domain-containing protein -
J3992_RS14235 (J3992_14220) 71146..71424 - 279 WP_001921601.1 DUF3709 domain-containing protein -
J3992_RS14240 (J3992_14225) 71542..71659 - 118 Protein_148 DUF3265 domain-containing protein -
J3992_RS14245 (J3992_14230) 71710..71988 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J3992_RS14250 (J3992_14235) 71981..72250 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
J3992_RS14255 (J3992_14240) 72398..72844 - 447 WP_000006157.1 hypothetical protein -
J3992_RS14260 (J3992_14245) 73094..73219 - 126 WP_001900195.1 DUF645 family protein -
J3992_RS14265 (J3992_14250) 73612..73884 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
J3992_RS14270 (J3992_14255) 73881..74378 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
J3992_RS14275 (J3992_14260) 74395..74463 - 69 Protein_155 acetyltransferase -
J3992_RS14280 (J3992_14265) 74528..74989 - 462 WP_001903091.1 lipocalin family protein -
J3992_RS14285 (J3992_14270) 75180..75716 - 537 WP_000469482.1 GNAT family protein -
J3992_RS14290 (J3992_14275) 75974..76195 - 222 WP_032467793.1 DUF1289 domain-containing protein -
J3992_RS14295 (J3992_14280) 76204..76317 - 114 WP_001900214.1 hypothetical protein -
J3992_RS14300 (J3992_14285) 76374..76760 - 387 WP_001015867.1 NUDIX hydrolase -
J3992_RS14305 (J3992_14290) 77004..77246 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J3992_RS14310 (J3992_14295) 77265..77582 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3992_RS14315 (J3992_14300) 77736..78074 - 339 WP_000713853.1 hypothetical protein -
J3992_RS14320 (J3992_14305) 78232..78936 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T206612 WP_000982260.1 NZ_CP077061:73881-74378 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T206612 NZ_CP102502:37583-37888 [Citrobacter youngae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT206612 WP_000246253.1 NZ_CP077061:73612-73884 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT206612 NZ_CP102502:37363-37581 [Citrobacter youngae]
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References