206611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 71710..72250 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag J3992_RS14250 Protein ID WP_000277238.1
Coordinates 71981..72250 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag J3992_RS14245 Protein ID WP_001258569.1
Coordinates 71710..71988 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS14180 (J3992_14165) 66769..66885 - 117 WP_086010881.1 DUF3265 domain-containing protein -
J3992_RS14185 (J3992_14170) 66882..67676 - 795 WP_001911581.1 hypothetical protein -
J3992_RS14190 (J3992_14175) 67772..68017 - 246 WP_000643598.1 hypothetical protein -
J3992_RS14195 (J3992_14180) 68004..68270 - 267 WP_000589156.1 BrnT family toxin -
J3992_RS14200 (J3992_14185) 68579..68857 - 279 WP_000280324.1 DUF3709 domain-containing protein -
J3992_RS14205 (J3992_14190) 69109..69351 - 243 WP_000107461.1 hypothetical protein -
J3992_RS14210 (J3992_14195) 69443..69592 - 150 WP_071908333.1 DUF3265 domain-containing protein -
J3992_RS14215 (J3992_14200) 69565..69816 - 252 WP_001890111.1 TIGR03643 family protein -
J3992_RS14220 (J3992_14205) 70011..70397 - 387 WP_000703163.1 VOC family protein -
J3992_RS14225 (J3992_14210) 70387..70488 - 102 WP_001921603.1 hypothetical protein -
J3992_RS14230 (J3992_14215) 70688..70786 - 99 WP_223225486.1 DUF3709 domain-containing protein -
J3992_RS14235 (J3992_14220) 71146..71424 - 279 WP_001921601.1 DUF3709 domain-containing protein -
J3992_RS14240 (J3992_14225) 71542..71659 - 118 Protein_148 DUF3265 domain-containing protein -
J3992_RS14245 (J3992_14230) 71710..71988 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J3992_RS14250 (J3992_14235) 71981..72250 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
J3992_RS14255 (J3992_14240) 72398..72844 - 447 WP_000006157.1 hypothetical protein -
J3992_RS14260 (J3992_14245) 73094..73219 - 126 WP_001900195.1 DUF645 family protein -
J3992_RS14265 (J3992_14250) 73612..73884 + 273 WP_000246253.1 DUF1778 domain-containing protein -
J3992_RS14270 (J3992_14255) 73881..74378 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
J3992_RS14275 (J3992_14260) 74395..74463 - 69 Protein_155 acetyltransferase -
J3992_RS14280 (J3992_14265) 74528..74989 - 462 WP_001903091.1 lipocalin family protein -
J3992_RS14285 (J3992_14270) 75180..75716 - 537 WP_000469482.1 GNAT family protein -
J3992_RS14290 (J3992_14275) 75974..76195 - 222 WP_032467793.1 DUF1289 domain-containing protein -
J3992_RS14295 (J3992_14280) 76204..76317 - 114 WP_001900214.1 hypothetical protein -
J3992_RS14300 (J3992_14285) 76374..76760 - 387 WP_001015867.1 NUDIX hydrolase -
J3992_RS14305 (J3992_14290) 77004..77246 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T206611 WP_000277238.1 NZ_CP077061:71981-72250 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T206611 NZ_CP102502:c6169-5864 [Citrobacter youngae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT206611 WP_001258569.1 NZ_CP077061:71710-71988 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT206611 NZ_CP102502:c6389-6171 [Citrobacter youngae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References