206610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 67772..68270 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag J3992_RS14195 Protein ID WP_000589156.1
Coordinates 68004..68270 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag J3992_RS14190 Protein ID WP_000643598.1
Coordinates 67772..68017 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS14145 (J3992_14125) 62853..63239 - 387 WP_000703163.1 VOC family protein -
J3992_RS14150 (J3992_14130) 63396..63902 - 507 WP_000393074.1 hypothetical protein -
J3992_RS14155 (J3992_14140) 64424..64609 - 186 WP_001999468.1 hypothetical protein -
J3992_RS14160 (J3992_14145) 64676..65035 - 360 WP_001071541.1 VOC family protein -
J3992_RS14165 (J3992_14150) 65188..66192 - 1005 WP_000964920.1 LD-carboxypeptidase -
J3992_RS14170 (J3992_14155) 66408..66590 - 183 WP_000923182.1 DUF645 family protein -
J3992_RS14175 (J3992_14160) 66651..66779 - 129 WP_071908338.1 general secretion pathway protein GspI -
J3992_RS14180 (J3992_14165) 66769..66885 - 117 WP_086010881.1 DUF3265 domain-containing protein -
J3992_RS14185 (J3992_14170) 66882..67676 - 795 WP_001911581.1 hypothetical protein -
J3992_RS14190 (J3992_14175) 67772..68017 - 246 WP_000643598.1 hypothetical protein Antitoxin
J3992_RS14195 (J3992_14180) 68004..68270 - 267 WP_000589156.1 BrnT family toxin Toxin
J3992_RS14200 (J3992_14185) 68579..68857 - 279 WP_000280324.1 DUF3709 domain-containing protein -
J3992_RS14205 (J3992_14190) 69109..69351 - 243 WP_000107461.1 hypothetical protein -
J3992_RS14210 (J3992_14195) 69443..69592 - 150 WP_071908333.1 DUF3265 domain-containing protein -
J3992_RS14215 (J3992_14200) 69565..69816 - 252 WP_001890111.1 TIGR03643 family protein -
J3992_RS14220 (J3992_14205) 70011..70397 - 387 WP_000703163.1 VOC family protein -
J3992_RS14225 (J3992_14210) 70387..70488 - 102 WP_001921603.1 hypothetical protein -
J3992_RS14230 (J3992_14215) 70688..70786 - 99 WP_223225486.1 DUF3709 domain-containing protein -
J3992_RS14235 (J3992_14220) 71146..71424 - 279 WP_001921601.1 DUF3709 domain-containing protein -
J3992_RS14240 (J3992_14225) 71542..71659 - 118 Protein_148 DUF3265 domain-containing protein -
J3992_RS14245 (J3992_14230) 71710..71988 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J3992_RS14250 (J3992_14235) 71981..72250 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
J3992_RS14255 (J3992_14240) 72398..72844 - 447 WP_000006157.1 hypothetical protein -
J3992_RS14260 (J3992_14245) 73094..73219 - 126 WP_001900195.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T206610 WP_000589156.1 NZ_CP077061:c68270-68004 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T206610 NZ_CP102501:c125337-125050 [Citrobacter youngae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT206610 WP_000643598.1 NZ_CP077061:c68017-67772 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT206610 NZ_CP102501:c125576-125337 [Citrobacter youngae]
ATGGGTAACATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References