Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1587345..1588013 Replicon chromosome
Accession NC_003098
Organism Streptococcus pneumoniae R6

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPR_RS08005 Protein ID WP_001132285.1
Coordinates 1587834..1588013 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPR_RS08000 Protein ID WP_000961810.1
Coordinates 1587345..1587797 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPR_RS07975 (spr1607) 1583235..1583978 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPR_RS07980 (spr1608) 1583980..1584930 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
SPR_RS07985 (spr1609) 1585068..1585496 - 429 WP_000418176.1 NUDIX hydrolase -
SPR_RS07990 (spr1610) 1585462..1586565 - 1104 WP_000719717.1 M50 family metallopeptidase -
SPR_RS07995 (spr1611) 1586584..1587054 - 471 WP_000257105.1 DUF3013 family protein -
SPR_RS08000 (spr1612) 1587345..1587797 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPR_RS08005 (spr1613) 1587834..1588013 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPR_RS08010 (spr1614) 1588150..1588329 - 180 WP_001809903.1 hypothetical protein -
SPR_RS08015 (spr1615) 1588494..1588733 - 240 WP_000818079.1 hypothetical protein -
SPR_RS08020 (spr1616) 1589003..1590274 + 1272 WP_001113205.1 replication-associated recombination protein A -
SPR_RS08030 (spr1617) 1590821..1592140 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
SPR_RS08035 (spr1618) 1592150..1592995 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T20661 WP_001132285.1 NC_003098:c1588013-1587834 [Streptococcus pneumoniae R6]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T20661 NC_003098:c1588013-1587834 [Streptococcus pneumoniae R6]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT20661 WP_000961810.1 NC_003098:c1587797-1587345 [Streptococcus pneumoniae R6]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT20661 NC_003098:c1587797-1587345 [Streptococcus pneumoniae R6]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References