206609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 58421..58980 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag J3992_RS14100 Protein ID WP_000578476.1
Coordinates 58702..58980 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag J3992_RS14095 Protein ID WP_000381183.1
Coordinates 58421..58705 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS14050 (J3992_14030) 54087..54176 - 90 WP_072606010.1 DUF3265 domain-containing protein -
J3992_RS14055 (J3992_14035) 54207..54905 - 699 WP_001890502.1 hypothetical protein -
J3992_RS14060 (J3992_14040) 55028..55654 - 627 WP_000365424.1 LysE family translocator -
J3992_RS14065 (J3992_14045) 55696..55788 - 93 WP_014378730.1 DUF3265 domain-containing protein -
J3992_RS14070 (J3992_14050) 55803..56276 - 474 WP_001161076.1 GrpB family protein -
J3992_RS14075 (J3992_14055) 56476..56658 - 183 WP_000923182.1 DUF645 family protein -
J3992_RS14080 (J3992_14060) 56719..56856 - 138 WP_001890145.1 hypothetical protein -
J3992_RS14085 (J3992_14065) 57050..57646 - 597 WP_000255434.1 hypothetical protein -
J3992_RS14090 (J3992_14070) 57711..58172 - 462 WP_001911578.1 lipocalin family protein -
J3992_RS14095 (J3992_14075) 58421..58705 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J3992_RS14100 (J3992_14080) 58702..58980 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J3992_RS14105 (J3992_14085) 59131..59544 - 414 WP_000049420.1 VOC family protein -
J3992_RS14110 (J3992_14090) 59619..59735 - 117 WP_086010882.1 DUF3265 domain-containing protein -
J3992_RS14115 (J3992_14095) 59732..60211 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
J3992_RS14120 (J3992_14100) 60424..61047 - 624 WP_000247070.1 DUF1349 domain-containing protein -
J3992_RS14125 (J3992_14105) 61253..61678 - 426 WP_000415750.1 hypothetical protein -
J3992_RS14130 (J3992_14110) 61825..61974 - 150 WP_071908333.1 DUF3265 domain-containing protein -
J3992_RS14135 (J3992_14115) 61947..62198 - 252 WP_001890111.1 TIGR03643 family protein -
J3992_RS14140 (J3992_14120) 62393..62596 - 204 WP_001911580.1 hypothetical protein -
J3992_RS14145 (J3992_14125) 62853..63239 - 387 WP_000703163.1 VOC family protein -
J3992_RS14150 (J3992_14130) 63396..63902 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T206609 WP_000578476.1 NZ_CP077061:58702-58980 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T206609 NZ_CP102501:120531-121013 [Citrobacter youngae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTTACCATGGATTTAAGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT206609 WP_000381183.1 NZ_CP077061:58421-58705 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT206609 NZ_CP102501:120277-120543 [Citrobacter youngae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTCCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References