Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 52055..52593 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag J3992_RS14035 Protein ID WP_000802136.1
Coordinates 52294..52593 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag J3992_RS14030 Protein ID WP_001107719.1
Coordinates 52055..52297 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS13995 (J3992_13975) 47471..47611 - 141 WP_001883049.1 DUF3265 domain-containing protein -
J3992_RS14000 (J3992_13980) 47577..48512 - 936 WP_000051985.1 restriction endonuclease -
J3992_RS14005 (J3992_13985) 48793..49392 - 600 WP_000429495.1 DUF6338 family protein -
J3992_RS14010 (J3992_13990) 49547..49813 - 267 WP_000937852.1 hypothetical protein -
J3992_RS14015 (J3992_13995) 50027..50710 - 684 WP_000877436.1 hypothetical protein -
J3992_RS14020 (J3992_14000) 51134..51226 - 93 WP_014164112.1 DUF3265 domain-containing protein -
J3992_RS14025 (J3992_14005) 51248..51826 - 579 WP_000110120.1 hypothetical protein -
J3992_RS14030 (J3992_14010) 52055..52297 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J3992_RS14035 (J3992_14015) 52294..52593 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3992_RS14040 (J3992_14020) 52721..53116 - 396 WP_000870857.1 DUF3465 domain-containing protein -
J3992_RS14045 (J3992_14025) 53330..53509 - 180 WP_001883058.1 DUF645 family protein -
J3992_RS14050 (J3992_14030) 54087..54176 - 90 WP_072606010.1 DUF3265 domain-containing protein -
J3992_RS14055 (J3992_14035) 54207..54905 - 699 WP_001890502.1 hypothetical protein -
J3992_RS14060 (J3992_14040) 55028..55654 - 627 WP_000365424.1 LysE family translocator -
J3992_RS14065 (J3992_14045) 55696..55788 - 93 WP_014378730.1 DUF3265 domain-containing protein -
J3992_RS14070 (J3992_14050) 55803..56276 - 474 WP_001161076.1 GrpB family protein -
J3992_RS14075 (J3992_14055) 56476..56658 - 183 WP_000923182.1 DUF645 family protein -
J3992_RS14080 (J3992_14060) 56719..56856 - 138 WP_001890145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T206608 WP_000802136.1 NZ_CP077061:52294-52593 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T206608 NZ_CP102501:90216-91541 [Citrobacter youngae]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT206608 WP_001107719.1 NZ_CP077061:52055-52297 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT206608 NZ_CP102501:89918-90211 [Citrobacter youngae]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References