206607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 36292..36870 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag J3992_RS13895 Protein ID WP_001180243.1
Coordinates 36553..36870 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag J3992_RS13890 Protein ID WP_000557292.1
Coordinates 36292..36534 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS13820 31692..31808 - 117 WP_001889170.1 hypothetical protein -
J3992_RS13825 (J3992_13805) 31771..31896 - 126 WP_001944767.1 DUF645 family protein -
J3992_RS13830 (J3992_13810) 31924..32034 - 111 Protein_66 acetyltransferase -
J3992_RS13835 (J3992_13815) 32073..32183 - 111 WP_134814058.1 DUF3265 domain-containing protein -
J3992_RS13840 (J3992_13820) 32180..32497 - 318 WP_001232701.1 HigA family addiction module antitoxin -
J3992_RS13845 (J3992_13825) 32508..32795 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3992_RS13850 (J3992_13830) 32836..32949 - 114 WP_001894955.1 hypothetical protein -
J3992_RS13855 (J3992_13835) 33062..33242 - 181 Protein_71 DUF645 family protein -
J3992_RS13860 (J3992_13840) 33667..33900 - 234 WP_032482776.1 DUF3709 domain-containing protein -
J3992_RS13865 (J3992_13845) 33921..34114 - 194 Protein_73 hypothetical protein -
J3992_RS13870 (J3992_13850) 34303..34521 - 219 WP_001917086.1 DUF3709 domain-containing protein -
J3992_RS13875 (J3992_13855) 34533..34742 - 210 WP_001900246.1 DUF3709 domain-containing protein -
J3992_RS13880 (J3992_13860) 34831..35484 - 654 WP_000226874.1 hypothetical protein -
J3992_RS13885 (J3992_13865) 35541..36050 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
J3992_RS13890 (J3992_13870) 36292..36534 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J3992_RS13895 (J3992_13875) 36553..36870 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3992_RS13900 (J3992_13880) 37064..37216 - 153 Protein_80 DUF645 family protein -
J3992_RS13905 (J3992_13885) 37277..37452 - 176 Protein_81 acetyltransferase -
J3992_RS13910 (J3992_13890) 37515..37808 - 294 WP_125460920.1 hypothetical protein -
J3992_RS13915 (J3992_13895) 37955..38302 - 348 WP_000933409.1 hypothetical protein -
J3992_RS13920 (J3992_13900) 38451..38876 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
J3992_RS13925 (J3992_13905) 39035..39145 - 111 WP_223804330.1 Tfp pilus assembly protein -
J3992_RS13930 39135..39197 - 63 Protein_86 DUF645 family protein -
J3992_RS13935 (J3992_13915) 39548..40084 - 537 WP_000644491.1 nucleotidyltransferase family protein -
J3992_RS13940 (J3992_13920) 40228..40623 - 396 WP_000046953.1 DUF6404 family protein -
J3992_RS13945 (J3992_13925) 40800..40919 - 120 WP_001900954.1 DUF645 family protein -
J3992_RS13950 (J3992_13930) 41042..41185 - 144 Protein_90 acetyltransferase -
J3992_RS13955 (J3992_13935) 41284..41679 - 396 WP_000046952.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T206607 WP_001180243.1 NZ_CP077061:36553-36870 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T206607 NZ_CP102500:4835189-4835500 [Citrobacter youngae]
GTGCATGTTATCAGCCGAAAACCATTCAATGAGGGTATGCTCATGTATCCAAACCATGGGCTTGCTCTCTCTGAGTTGCT
GAATGTTTTGGAGAAAAAAACATTCCATCACCCTGAAGAGATGAAACAGTATATTCCTTCTCTTGATAATTTTAAGTACA
GGAATAAATGGTGGGTAATTGATGTTTCTGGTAACAACCTGAGACTCATTGCCTACATAGATTTCAGGTTACATAAGGTA
TTTGTGAAGCATATCGTTCTCCACGCCGAATATGACAAACTGACAGAATATTATCGGGGCCATAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT206607 WP_000557292.1 NZ_CP077061:36292-36534 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT206607 NZ_CP102500:4835497-4835943 [Citrobacter youngae]
ATGAGATCTCATCGTCATATGGACGCAGCCAGCGCAAAAAAGATCGTTGATACCTTCAGTTGTGCTGTAAAAACGATCCC
TCTTTTGGGGGAAGAACGCAATGAAACGGAGTATCGAAGGGCACTAGCGCTAGTAGAGTTTCTGGTTGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTTAGTGCCCGAATCAGTGAATACGAAAAACATGCACCAGAATTCAGAGCGCTCAAT
CAACACCTGAAACAAATTCCCCCTGGCGTTTCCGTATTGCGTACGCTCATGGATCAGTACGGATTAAAAGCCACCGACCT
CGCCAACGAACTTGGTTCTAAATCGAACGTCAGTAACATCCTAAATGGCCGTAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAAACTTCCGGCAGATGCATTTATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References