Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 26925..27453 | Replicon | chromosome |
| Accession | NZ_CP077061 | ||
| Organism | Vibrio cholerae strain MS84A | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | J3992_RS13785 | Protein ID | WP_000221352.1 |
| Coordinates | 27163..27453 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | J3992_RS13780 | Protein ID | WP_000213183.1 |
| Coordinates | 26925..27173 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3992_RS13745 (J3992_13730) | 21964..22428 | + | 465 | WP_000140244.1 | hypothetical protein | - |
| J3992_RS13750 (J3992_13735) | 22528..22926 | - | 399 | WP_001882293.1 | hypothetical protein | - |
| J3992_RS13755 (J3992_13740) | 23082..23582 | - | 501 | WP_000789723.1 | hypothetical protein | - |
| J3992_RS13760 (J3992_13745) | 23720..24250 | - | 531 | WP_000415563.1 | hypothetical protein | - |
| J3992_RS13765 (J3992_13750) | 24401..24796 | - | 396 | WP_000649527.1 | DUF3465 domain-containing protein | - |
| J3992_RS13770 (J3992_13755) | 25004..25429 | - | 426 | WP_000415752.1 | hypothetical protein | - |
| J3992_RS13775 (J3992_13760) | 25701..26354 | - | 654 | WP_000036957.1 | site-specific DNA-methyltransferase | - |
| J3992_RS13780 (J3992_13765) | 26925..27173 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J3992_RS13785 (J3992_13770) | 27163..27453 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J3992_RS13790 (J3992_13775) | 27589..28050 | - | 462 | WP_001911752.1 | lipocalin family protein | - |
| J3992_RS13795 (J3992_13780) | 28241..28717 | - | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| J3992_RS13800 (J3992_13785) | 28745..28855 | - | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| J3992_RS13805 (J3992_13790) | 28852..29781 | - | 930 | WP_000335802.1 | hypothetical protein | - |
| J3992_RS13810 (J3992_13795) | 29901..30347 | - | 447 | WP_000128977.1 | hypothetical protein | - |
| J3992_RS13815 (J3992_13800) | 30500..31504 | - | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| J3992_RS13820 | 31692..31808 | - | 117 | WP_001889170.1 | hypothetical protein | - |
| J3992_RS13825 (J3992_13805) | 31771..31896 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| J3992_RS13830 (J3992_13810) | 31924..32034 | - | 111 | Protein_66 | acetyltransferase | - |
| J3992_RS13835 (J3992_13815) | 32073..32183 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 1..1044173 | 1044172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T206605 WP_000221352.1 NZ_CP077061:27163-27453 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T206605 NZ_CP102500:4687086-4687364 [Citrobacter youngae]
ATGAATAAGCTTACTCAGTACGATCCCGCAGCTGCGCTGGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCATTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAGCATCGCGGCAG
AAACGGGGTTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG
ATGAATAAGCTTACTCAGTACGATCCCGCAGCTGCGCTGGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCATTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAGCATCGCGGCAG
AAACGGGGTTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT206605 WP_000213183.1 NZ_CP077061:26925-27173 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT206605 NZ_CP102500:4686776-4687093 [Citrobacter youngae]
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAACAGAATCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACGATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGATTATCAGGAGACCTTCCGCCATGAATAA
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAACAGAATCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACGATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGATTATCAGGAGACCTTCCGCCATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |