Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 2207..3006 | Replicon | chromosome |
| Accession | NZ_CP077061 | ||
| Organism | Vibrio cholerae strain MS84A | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | J3992_RS13525 | Protein ID | WP_000118351.1 |
| Coordinates | 2207..2740 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0K9UER4 |
| Locus tag | J3992_RS13530 | Protein ID | WP_000179600.1 |
| Coordinates | 2737..3006 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3992_RS13505 (J3992_13500) | 307..1224 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
| J3992_RS13510 (J3992_13505) | 1458..1760 | - | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J3992_RS13515 (J3992_13510) | 1748..2005 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J3992_RS13520 (J3992_13515) | 2087..2197 | - | 111 | WP_086010065.1 | DUF3265 domain-containing protein | - |
| J3992_RS13525 (J3992_13520) | 2207..2740 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| J3992_RS13530 (J3992_13525) | 2737..3006 | - | 270 | WP_000179600.1 | DUF1778 domain-containing protein | Antitoxin |
| J3992_RS13535 (J3992_13530) | 3229..3600 | - | 372 | WP_001164080.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| J3992_RS13540 (J3992_13535) | 3741..4028 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| J3992_RS13545 (J3992_13540) | 4180..4848 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| J3992_RS13550 (J3992_13545) | 4865..4927 | - | 63 | Protein_10 | acetyltransferase | - |
| J3992_RS13555 (J3992_13550) | 5079..5351 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| J3992_RS13560 (J3992_13555) | 5348..5845 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| J3992_RS13565 (J3992_13560) | 5862..5930 | - | 69 | Protein_13 | acetyltransferase | - |
| J3992_RS13570 | 6047..6151 | - | 105 | WP_228840819.1 | DUF645 family protein | - |
| J3992_RS13575 (J3992_13570) | 6342..6464 | - | 123 | Protein_15 | acetyltransferase | - |
| J3992_RS13580 (J3992_13575) | 6521..6976 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| J3992_RS13585 (J3992_13580) | 7104..7391 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J3992_RS13590 (J3992_13585) | 7381..7632 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 1..1044173 | 1044172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T206600 WP_000118351.1 NZ_CP077061:c2740-2207 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T206600 NZ_CP102500:c3921025-3920657 [Citrobacter youngae]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTT
ACCTCTCAGGTGCAAGCACCATATTTGACTACGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGCTGATGAGCCGGTA
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTT
ACCTCTCAGGTGCAAGCACCATATTTGACTACGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGCTGATGAGCCGGTA
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9924.49 Da Isoelectric Point: 4.9107
>AT206600 WP_000179600.1 NZ_CP077061:c3006-2737 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK
Download Length: 270 bp
>AT206600 NZ_CP102500:c3921363-3921046 [Citrobacter youngae]
ATGAGTAACATCACCTGGGGCCTGCAGCGGAATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTATGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAACGCTAA
ATGAGTAACATCACCTGGGGCCTGCAGCGGAATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTATGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9KM94 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UER4 |