Detailed information of TA system TA206598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2209200..2211025
• Replicon: chromosome
• Accession: NZ_CP077060
• Organism: Vibrio cholerae strain MS84A

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0K9UVP8
• Locus tag: J3992_RS09985
• Protein ID: WP_000392003.1
• Coordinates: 2209200..2210561 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J3992_RS09990
• Protein ID: WP_000804849.1
• Coordinates: 2210558..2211025 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3992_RS09970 (J3992_09960)	2205051..2206571	+	1521	WP_000640055.1	aldehyde dehydrogenase family protein	-
J3992_RS09975 (J3992_09965)	2206913..2207593	+	681	Protein_1933	IS5 family transposase	-
J3992_RS09980 (J3992_09970)	2207619..2208596	-	978	WP_001889101.1	IS481-like element ISVch1 family transposase	-
J3992_RS09985 (J3992_09975)	2209200..2210561	+	1362	WP_000392003.1	type II toxin-antitoxin system HipA family toxin	Toxin
J3992_RS09990 (J3992_09980)	2210558..2211025	+	468	WP_000804849.1	helix-turn-helix transcriptional regulator	Antitoxin
J3992_RS09995 (J3992_09985)	2211453..2212031	+	579	WP_000109982.1	class I SAM-dependent methyltransferase	-
J3992_RS10000 (J3992_09990)	2212035..2214971	+	2937	WP_001283872.1	DEAD/DEAH box helicase family protein	-
J3992_RS10005 (J3992_09995)	2215041..2215745	+	705	WP_001880605.1	nuclease-related domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51246.17 Da
• Isoelectric Point: 4.9109

>T206598 WP_000392003.1 NZ_CP077060:2209200-2210561 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T206598 NZ_CP102500:c3016390-3016037 [Citrobacter youngae]
ATGTGGACAATTAAAACTACGGATCGGTTTGACGATTGGTTTAGCGCGCTCTGCGCAACCGATCGGGCCTGTGTGCTGGC
GTCGCTACTCGTTCTGCGGGAAAAGGGGCCGGGATTGCCCAGACCTTATGCCGACACGATCAAAGGTTCCTGCTACAACA
ACATGAAAGAGTTGCGTGTGCAGAGCCGGGGCGATCCGATACGAATATTTTTCGCCTTCGACCCTTACCGAACGGGCATT
CTGCTTTGTGCTGGTAATAAGGTCGGTAATGAAAAACGCTTTTATAATCAGATGGTCGCGGTTGCCGACCGGGAATTTGC
TGAGTATCTGAATACGTTAGATGATAAGGAGTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17095.51 Da
• Isoelectric Point: 10.6157

>AT206598 WP_000804849.1 NZ_CP077060:2210558-2211025 [Vibrio cholerae]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT206598 NZ_CP102500:c3016032-3015730 [Citrobacter youngae]
ATGGGCAGAACGCTCGAACAGCTTCTTGCAGATGAAAAACGGGACATTGTGGCCGATGCGCAGGCGATGGCGGCAGACAT
CCTGCTTAACATCCACCTTGCCGAACTGCGTGAGAAAGTGCAGAAAACGCAGGTAGAAATGGCTCAGACTTTGGGCATCC
GGCAACCTACCGTCGCCAGCATGGAAAAGCCAGGACGCGATCTGAAACTGTCCACGCTGAAACGTTACGTTGAGGCGACC
GGCGGCAAGCTACGCCTTGATATTGAACTGCCGGATGGCTCTCACTACGGATTTGTACTGTAA

Structures

Toxin

• AlphaFold DB: A0A0K9UVP8