Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4952556..4953213 Replicon chromosome
Accession NZ_CP076863
Organism Klebsiella pneumoniae strain V3

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KRP25_RS24105 Protein ID WP_064143361.1
Coordinates 4952803..4953213 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KRP25_RS24100 Protein ID WP_002916312.1
Coordinates 4952556..4952822 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP25_RS24075 (4947764) 4947764..4949197 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
KRP25_RS24080 (4949316) 4949316..4950044 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KRP25_RS24085 (4950094) 4950094..4950405 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KRP25_RS24090 (4950569) 4950569..4951228 + 660 WP_004174454.1 hemolysin III family protein -
KRP25_RS24095 (4951327) 4951327..4952310 - 984 WP_217046741.1 tRNA-modifying protein YgfZ -
KRP25_RS24100 (4952556) 4952556..4952822 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KRP25_RS24105 (4952803) 4952803..4953213 + 411 WP_064143361.1 protein YgfX Toxin
KRP25_RS24110 (4953220) 4953220..4953741 - 522 WP_217046742.1 flavodoxin FldB -
KRP25_RS24115 (4953842) 4953842..4954738 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KRP25_RS24120 (4954761) 4954761..4955474 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KRP25_RS24125 (4955480) 4955480..4957213 + 1734 WP_217046743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16048.91 Da        Isoelectric Point: 11.7330

>T206597 WP_064143361.1 NZ_CP076863:4952803-4953213 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQK

Download         Length: 411 bp

>T206597 NZ_CP102500:2118080-2118183 [Citrobacter youngae]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT206597 WP_002916312.1 NZ_CP076863:4952556-4952822 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206597 NZ_CP102500:c2118188-2117978 [Citrobacter youngae]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCGACTAAAGTGGT
CTGAAAAAAAGGGAGATTGTCACTCGCTACAATGTAAAAACCGCAAGTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References