Detailed information of TA system TA206588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1381162..1382750
• Replicon: chromosome
• Accession: NZ_CP076863
• Organism: Klebsiella pneumoniae strain V3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KRP25_RS06805
• Protein ID: WP_217048316.1
• Coordinates: 1381162..1382484 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KRP25_RS06810
• Protein ID: WP_156664135.1
• Coordinates: 1382484..1382750 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRP25_RS06790 (1376218)	1376218..1378719	+	2502	WP_217048313.1	fimbria/pilus outer membrane usher protein	-
KRP25_RS06795 (1378707)	1378707..1379711	+	1005	WP_217048314.1	fimbrial protein	-
KRP25_RS06800 (1379853)	1379853..1381145	+	1293	WP_217048315.1	glycoside hydrolase family 10 protein	-
KRP25_RS06805 (1381162)	1381162..1382484	-	1323	WP_217048316.1	type II toxin-antitoxin system HipA family toxin	Toxin
KRP25_RS06810 (1382484)	1382484..1382750	-	267	WP_156664135.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KRP25_RS06815 (1383138)	1383138..1383464	-	327	WP_217048317.1	hydroxyisourate hydrolase	-
KRP25_RS06820 (1383461)	1383461..1383961	-	501	WP_004224756.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KRP25_RS06825 (1383939)	1383939..1385318	-	1380	WP_217048318.1	nucleobase:cation symporter-2 family protein	-
KRP25_RS06830 (1385664)	1385664..1386818	+	1155	WP_217048319.1	FAD-dependent urate hydroxylase HpxO	-
KRP25_RS06835 (1386799)	1386799..1387722	-	924	WP_156661854.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49138.48 Da
• Isoelectric Point: 8.2603

>T206588 WP_217048316.1 NZ_CP076863:c1382484-1381162 [Klebsiella pneumoniae]
MATLTTRMNNVRVGTLTRPANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILREFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T206588 NZ_CP102490:c4762408-4762124 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9837.22 Da
• Isoelectric Point: 7.1994

>AT206588 WP_156664135.1 NZ_CP076863:c1382750-1382484 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALAGRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT206588 NZ_CP102490:c4762640-4762398 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAACAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA