Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mbcAT/RES-Xre |
| Location | 7547..8445 | Replicon | plasmid pP7a |
| Accession | NZ_CP076857 | ||
| Organism | Mycobacterium avium subsp. hominissuis strain OCU873s_P7_4s | ||
Toxin (Protein)
| Gene name | mbcT | Uniprot ID | A0A859PX34 |
| Locus tag | BJP74_RS23460 | Protein ID | WP_023870434.1 |
| Coordinates | 7885..8445 (+) | Length | 187 a.a. |
Antitoxin (Protein)
| Gene name | mbcA | Uniprot ID | A0A859PYE6 |
| Locus tag | BJP74_RS23455 | Protein ID | WP_023870435.1 |
| Coordinates | 7547..7888 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BJP74_RS23425 (BJP74_24035) | 2581..3423 | + | 843 | WP_023870443.1 | ParB/RepB/Spo0J family partition protein | - |
| BJP74_RS23430 (BJP74_24040) | 3639..3890 | + | 252 | WP_023870442.1 | ribbon-helix-helix protein, CopG family | - |
| BJP74_RS23435 (BJP74_24045) | 3887..4303 | + | 417 | WP_023870441.1 | type II toxin-antitoxin system VapC family toxin | - |
| BJP74_RS23440 (BJP74_24050) | 4408..4848 | - | 441 | WP_023870440.1 | hypothetical protein | - |
| BJP74_RS23445 (BJP74_24055) | 5024..5185 | + | 162 | WP_023870439.1 | hypothetical protein | - |
| BJP74_RS23450 (BJP74_24060) | 6307..7458 | - | 1152 | WP_023870436.1 | hypothetical protein | - |
| BJP74_RS23455 (BJP74_24065) | 7547..7888 | + | 342 | WP_023870435.1 | DUF2384 domain-containing protein | Antitoxin |
| BJP74_RS23460 (BJP74_24070) | 7885..8445 | + | 561 | WP_023870434.1 | RES domain-containing protein | Toxin |
| BJP74_RS23465 (BJP74_24075) | 8661..9011 | - | 351 | WP_023870433.1 | hypothetical protein | - |
| BJP74_RS23470 (BJP74_24080) | 9008..10711 | - | 1704 | WP_158423352.1 | WXG100 family type VII secretion target | - |
| BJP74_RS23475 (BJP74_24085) | 10728..11033 | - | 306 | WP_023870373.1 | type VII secretion target | - |
| BJP74_RS23480 (BJP74_24090) | 11109..11414 | - | 306 | WP_134798478.1 | hypothetical protein | - |
| BJP74_RS23485 (BJP74_24095) | 11444..12988 | - | 1545 | WP_134798479.1 | DUF4226 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | esxN / eccA5 / esxN | 1..396301 | 396301 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20272.58 Da Isoelectric Point: 4.8677
>T206578 WP_023870434.1 NZ_CP076857:7885-8445 [Mycobacterium avium subsp. hominissuis]
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK
Download Length: 561 bp
>T206578 NZ_CP102489:2058-2333 [Escherichia coli O15:H18]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAAGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAGCCCAGGGAGATCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAAGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAGCCCAGGGAGATCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 114 a.a. Molecular weight: 12350.16 Da Isoelectric Point: 5.0916
>AT206578 WP_023870435.1 NZ_CP076857:7547-7888 [Mycobacterium avium subsp. hominissuis]
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV
Download Length: 342 bp
>AT206578 NZ_CP102489:1774-2058 [Escherichia coli O15:H18]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAAACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AACGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAAACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AACGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A859PX34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A859PYE6 |