Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 75287..75858 | Replicon | plasmid pNi1-3 |
| Accession | NZ_CP076856 | ||
| Organism | Shewanella decolorationis strain Ni1-3 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A2I8S8S5 |
| Locus tag | D0436_RS22300 | Protein ID | WP_011918375.1 |
| Coordinates | 75287..75598 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A1Z3MW28 |
| Locus tag | D0436_RS22305 | Protein ID | WP_011787805.1 |
| Coordinates | 75598..75858 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D0436_RS22275 (D0436_24480) | 70315..70539 | + | 225 | WP_011839958.1 | DUF6290 family protein | - |
| D0436_RS22280 (D0436_24485) | 70523..70789 | + | 267 | WP_011839957.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| D0436_RS22285 (D0436_24490) | 70782..71165 | + | 384 | WP_216832064.1 | hypothetical protein | - |
| D0436_RS22290 (D0436_24495) | 71188..72186 | - | 999 | WP_254803679.1 | replication initiation protein | - |
| D0436_RS22295 (D0436_24500) | 72183..75263 | - | 3081 | WP_011787830.1 | Tn3 family transposase | - |
| D0436_RS22300 (D0436_24505) | 75287..75598 | - | 312 | WP_011918375.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| D0436_RS22305 (D0436_24510) | 75598..75858 | - | 261 | WP_011787805.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| D0436_RS22310 (D0436_24515) | 76090..76617 | + | 528 | Protein_70 | primase C-terminal domain-containing protein | - |
| D0436_RS22315 (D0436_24520) | 76803..77117 | + | 315 | WP_039920606.1 | hypothetical protein | - |
| D0436_RS22320 (D0436_24525) | 77428..77733 | - | 306 | WP_209000265.1 | DUF2845 domain-containing protein | - |
| D0436_RS22325 (D0436_24530) | 77922..79226 | - | 1305 | WP_010793081.1 | IS1380-like element ISPa33 family transposase | - |
| D0436_RS22330 (D0436_24535) | 79306..79815 | - | 510 | WP_181159865.1 | hypothetical protein | - |
| D0436_RS22335 (D0436_24540) | 79819..80637 | - | 819 | WP_209000266.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..286397 | 286397 | |
| - | flank | IS/Tn | - | - | 77922..79226 | 1304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11862.70 Da Isoelectric Point: 8.5341
>T206576 WP_011918375.1 NZ_CP076856:c75598-75287 [Shewanella decolorationis]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
Download Length: 312 bp
>T206576 NZ_CP102488:c4629541-4629164 [Escherichia coli O15:H18]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9312.71 Da Isoelectric Point: 6.4546
>AT206576 WP_011787805.1 NZ_CP076856:c75858-75598 [Shewanella decolorationis]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD
Download Length: 261 bp
>AT206576 NZ_CP102488:c4629998-4629618 [Escherichia coli O15:H18]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I8S8S5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Z3MW28 |