206574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 67615..68186 Replicon plasmid pNi1-3
Accession NZ_CP076856
Organism Shewanella decolorationis strain Ni1-3

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag D0436_RS22255 Protein ID WP_011918375.1
Coordinates 67615..67926 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag D0436_RS22260 Protein ID WP_011787805.1
Coordinates 67926..68186 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0436_RS22245 (D0436_24450) 62634..64370 + 1737 WP_208660857.1 DUF4942 domain-containing protein -
D0436_RS22250 (D0436_24455) 64511..67591 - 3081 WP_011787830.1 Tn3 family transposase -
D0436_RS22255 (D0436_24460) 67615..67926 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0436_RS22260 (D0436_24465) 67926..68186 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0436_RS22265 (D0436_24470) 69398..69766 + 369 Protein_61 conjugal transfer transcriptional regulator TraJ -
D0436_RS22270 (D0436_24475) 69949..70218 + 270 WP_216832063.1 hypothetical protein -
D0436_RS22275 (D0436_24480) 70315..70539 + 225 WP_011839958.1 DUF6290 family protein -
D0436_RS22280 (D0436_24485) 70523..70789 + 267 WP_011839957.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0436_RS22285 (D0436_24490) 70782..71165 + 384 WP_216832064.1 hypothetical protein -
D0436_RS22290 (D0436_24495) 71188..72186 - 999 WP_254803679.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..286397 286397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T206574 WP_011918375.1 NZ_CP076856:c67926-67615 [Shewanella decolorationis]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T206574 NZ_CP102488:4466355-4466669 [Escherichia coli O15:H18]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT206574 WP_011787805.1 NZ_CP076856:c68186-67926 [Shewanella decolorationis]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT206574 NZ_CP102488:4466666-4467082 [Escherichia coli O15:H18]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References