Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 669316..669899 Replicon chromosome
Accession NZ_CP076853
Organism Rhizobium sp. WYJ-E13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KQ933_RS03290 Protein ID WP_216757374.1
Coordinates 669316..669570 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KQ933_RS03295 Protein ID WP_216757375.1
Coordinates 669567..669899 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ933_RS03265 (KQ933_03265) 665385..666155 + 771 WP_216757369.1 SDR family oxidoreductase -
KQ933_RS03270 (KQ933_03270) 666195..666896 - 702 WP_216757370.1 YafY family protein -
KQ933_RS03275 (KQ933_03275) 667023..667658 + 636 WP_216757371.1 LysE family translocator -
KQ933_RS03280 (KQ933_03280) 667789..668232 + 444 WP_216757372.1 cytochrome c -
KQ933_RS03285 (KQ933_03285) 668363..669277 + 915 WP_216757373.1 cytochrome c -
KQ933_RS03290 (KQ933_03290) 669316..669570 + 255 WP_216757374.1 type II toxin-antitoxin system HicA family toxin Toxin
KQ933_RS03295 (KQ933_03295) 669567..669899 + 333 WP_216757375.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQ933_RS03300 (KQ933_03300) 669946..670224 + 279 WP_216757376.1 hypothetical protein -
KQ933_RS03305 (KQ933_03305) 670244..670822 - 579 WP_216757377.1 type 1 glutamine amidotransferase family protein -
KQ933_RS03310 (KQ933_03310) 670863..671357 - 495 WP_216757378.1 GNAT family N-acetyltransferase -
KQ933_RS03315 (KQ933_03315) 671637..671909 + 273 WP_216757379.1 Ni(II)/Co(II)-sensing transcriptional repressor DmeR -
KQ933_RS03320 (KQ933_03320) 671933..672886 + 954 WP_216757380.1 CDF family Co(II)/Ni(II) efflux transporter DmeF -
KQ933_RS03325 (KQ933_03325) 672958..673845 + 888 WP_216757381.1 class A beta-lactamase -
KQ933_RS03330 (KQ933_03330) 673922..674164 - 243 WP_216757382.1 DUF1127 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-73)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9579.00 Da        Isoelectric Point: 10.0076

>T206566 WP_216757374.1 NZ_CP076853:669316-669570 [Rhizobium sp. WYJ-E13]
MNARHRKTLAAIFRDPVSGTIAWADVEGLLIAVGCHVVEGNGSRVRFEKDGHLAFFHRPHPEKEAKRYQIRDARRFLLEI
GIET

Download         Length: 255 bp

>T206566 NZ_CP102488:2797299-2797451 [Escherichia coli O15:H18]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12137.69 Da        Isoelectric Point: 4.9380

>AT206566 WP_216757375.1 NZ_CP076853:669567-669899 [Rhizobium sp. WYJ-E13]
MNVMEYKGYAARIEFDAEDEIFFGNIAGIADVVGFHADTVEGLKVAFHEAVDDYIETCRRLGKEPHKSYSGRMMFRVDPD
VHARAAKAAELAGKSLNQWAEEVLSKAAAA

Download         Length: 333 bp

>AT206566 NZ_CP102488:c2797250-2797193 [Escherichia coli O15:H18]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References