Detailed information of TA system TA206563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-TIGR02293
• Location: 2475790..2476688
• Replicon: chromosome
• Accession: NZ_CP076851
• Organism: Mycobacterium avium subsp. hominissuis strain CAM177

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: BB735_RS11740
• Protein ID: WP_084024225.1
• Coordinates: 2475790..2476350 (-)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: BB735_RS11745
• Protein ID: WP_084024227.1
• Coordinates: 2476347..2476688 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB735_RS11715 (BB735_011715)	2470843..2471712	+	870	WP_099270689.1	hypothetical protein	-
BB735_RS11720 (BB735_011720)	2471782..2472123	+	342	WP_084024221.1	hypothetical protein	-
BB735_RS11725 (BB735_011725)	2472371..2473603	+	1233	WP_044543912.1	IS21 family transposase	-
BB735_RS11730 (BB735_011730)	2473600..2474403	+	804	WP_044543911.1	IS21-like element helper ATPase IstB	-
BB735_RS11735 (BB735_011735)	2474599..2475732	+	1134	WP_084024223.1	hypothetical protein	-
BB735_RS11740 (BB735_011740)	2475790..2476350	-	561	WP_084024225.1	RES domain-containing protein	Toxin
BB735_RS11745 (BB735_011745)	2476347..2476688	-	342	WP_084024227.1	DUF2384 domain-containing protein	Antitoxin
BB735_RS11750 (BB735_011750)	2476775..2477926	+	1152	WP_158295305.1	hypothetical protein	-
BB735_RS11755 (BB735_011755)	2478622..2478999	-	378	WP_235004214.1	DUF732 domain-containing protein	-
BB735_RS11760 (BB735_011760)	2479302..2479946	+	645	WP_084024233.1	class I SAM-dependent methyltransferase	-
BB735_RS11765 (BB735_011765)	2480149..2480406	+	258	Protein_2322	acyl-CoA dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2473600..2474403	803

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (25-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 20306.78 Da
• Isoelectric Point: 4.6089

>T206563 WP_084024225.1 NZ_CP076851:c2476350-2475790 [Mycobacterium avium subsp. hominissuis]
VSEALDEGLVQRIDARGTTEWSGTCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERVAQAASTT
AEKMLEATYRLHTIDVTDLAVLDLRTPDAREAVGLENDDIYGDDWSACQAVGHAAWFLHMQGVLVPAAGGVGVVVTAYEQ
RTRPGQLQLRQSVDLTPVLYQELRAT

Nucleotide

• Length: 561 bp

>T206563 NZ_CP102488:1563639-1564133 [Escherichia coli O15:H18]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12474.31 Da
• Isoelectric Point: 4.8483

>AT206563 WP_084024227.1 NZ_CP076851:c2476688-2476347 [Mycobacterium avium subsp. hominissuis]
MGVNALASTVSGAIERLGLTYEEVGEIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Nucleotide

• Length: 342 bp

>AT206563 NZ_CP102488:1563349-1563642 [Escherichia coli O15:H18]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA