Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2400353..2401351 Replicon chromosome
Accession NZ_CP076851
Organism Mycobacterium avium subsp. hominissuis strain CAM177

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag BB735_RS11360 Protein ID WP_003876749.1
Coordinates 2400773..2401351 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A049EEK5
Locus tag BB735_RS11355 Protein ID WP_009976725.1
Coordinates 2400353..2400742 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB735_RS11335 (BB735_011335) 2395488..2396168 - 681 WP_196243699.1 hypothetical protein -
BB735_RS11340 (BB735_011340) 2396248..2397765 + 1518 WP_011724808.1 carboxylesterase/lipase family protein -
BB735_RS11345 (BB735_011345) 2397784..2399781 + 1998 WP_023869123.1 phosphotransferase -
BB735_RS11350 (BB735_011350) 2399778..2400272 + 495 WP_023869124.1 gluconokinase -
BB735_RS11355 (BB735_011355) 2400353..2400742 + 390 WP_009976725.1 hypothetical protein Antitoxin
BB735_RS11360 (BB735_011360) 2400773..2401351 + 579 WP_003876749.1 zeta toxin family protein Toxin
BB735_RS11365 (BB735_011365) 2401356..2402423 - 1068 WP_023869125.1 DoxX family protein -
BB735_RS11370 (BB735_011370) 2402534..2403094 + 561 WP_155251422.1 pyrazinamidase PncA -
BB735_RS11375 (BB735_011375) 2403094..2403894 + 801 WP_031354074.1 nuclear transport factor 2 family protein -
BB735_RS11380 (BB735_011380) 2403908..2404258 - 351 WP_003878038.1 DoxX family protein -
BB735_RS11385 (BB735_011385) 2404427..2405356 + 930 Protein_2247 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T206562 WP_003876749.1 NZ_CP076851:2400773-2401351 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T206562 NZ_CP102488:1346949-1347056 [Escherichia coli O15:H18]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13598.04 Da        Isoelectric Point: 5.6717

>AT206562 WP_009976725.1 NZ_CP076851:2400353-2400742 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT206562 NZ_CP102488:c1346899-1346836 [Escherichia coli O15:H18]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A049EEK5

References