Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2103443..2104107 Replicon chromosome
Accession NZ_CP076851
Organism Mycobacterium avium subsp. hominissuis strain CAM177

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag BB735_RS10070 Protein ID WP_023861453.1
Coordinates 2103700..2104107 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag BB735_RS10065 Protein ID WP_033719712.1
Coordinates 2103443..2103703 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB735_RS10045 (BB735_010045) 2098861..2099523 + 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -
BB735_RS10050 (BB735_010050) 2099718..2101178 + 1461 WP_033719709.1 serine/threonine-protein kinase -
BB735_RS10055 (BB735_010055) 2101376..2102644 - 1269 WP_033719710.1 cytochrome P450 -
BB735_RS10060 (BB735_010060) 2102810..2103262 + 453 WP_033719711.1 VOC family protein -
BB735_RS10065 (BB735_010065) 2103443..2103703 + 261 WP_033719712.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BB735_RS10070 (BB735_010070) 2103700..2104107 + 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
BB735_RS10075 (BB735_010075) 2104254..2105818 - 1565 Protein_1989 protein kinase -
BB735_RS10080 (BB735_010080) 2106055..2106576 + 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
BB735_RS10085 (BB735_010085) 2106573..2107118 + 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
BB735_RS10090 (BB735_010090) 2107239..2107769 + 531 WP_019734505.1 TetR/AcrR family transcriptional regulator -
BB735_RS10095 (BB735_010095) 2107758..2108927 - 1170 WP_033719716.1 acyl-CoA dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-125)

Antitoxin

(1-64)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T206561 WP_023861453.1 NZ_CP076851:2103700-2104107 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T206561 NZ_CP102488:1346414-1346521 [Escherichia coli O15:H18]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT206561 WP_033719712.1 NZ_CP076851:2103443-2103703 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT206561 NZ_CP102488:c1346361-1346300 [Escherichia coli O15:H18]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2


Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References