Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-PHD |
Location | 2103443..2104107 | Replicon | chromosome |
Accession | NZ_CP076851 | ||
Organism | Mycobacterium avium subsp. hominissuis strain CAM177 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A2A2ZII2 |
Locus tag | BB735_RS10070 | Protein ID | WP_023861453.1 |
Coordinates | 2103700..2104107 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A2A2ZI58 |
Locus tag | BB735_RS10065 | Protein ID | WP_033719712.1 |
Coordinates | 2103443..2103703 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BB735_RS10045 (BB735_010045) | 2098861..2099523 | + | 663 | WP_023861449.1 | TetR/AcrR family transcriptional regulator | - |
BB735_RS10050 (BB735_010050) | 2099718..2101178 | + | 1461 | WP_033719709.1 | serine/threonine-protein kinase | - |
BB735_RS10055 (BB735_010055) | 2101376..2102644 | - | 1269 | WP_033719710.1 | cytochrome P450 | - |
BB735_RS10060 (BB735_010060) | 2102810..2103262 | + | 453 | WP_033719711.1 | VOC family protein | - |
BB735_RS10065 (BB735_010065) | 2103443..2103703 | + | 261 | WP_033719712.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
BB735_RS10070 (BB735_010070) | 2103700..2104107 | + | 408 | WP_023861453.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
BB735_RS10075 (BB735_010075) | 2104254..2105818 | - | 1565 | Protein_1989 | protein kinase | - |
BB735_RS10080 (BB735_010080) | 2106055..2106576 | + | 522 | WP_033719714.1 | carboxymuconolactone decarboxylase family protein | - |
BB735_RS10085 (BB735_010085) | 2106573..2107118 | + | 546 | WP_033719715.1 | carboxymuconolactone decarboxylase family protein | - |
BB735_RS10090 (BB735_010090) | 2107239..2107769 | + | 531 | WP_019734505.1 | TetR/AcrR family transcriptional regulator | - |
BB735_RS10095 (BB735_010095) | 2107758..2108927 | - | 1170 | WP_033719716.1 | acyl-CoA dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 14414.44 Da Isoelectric Point: 4.5860
>T206561 WP_023861453.1 NZ_CP076851:2103700-2104107 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV
Download Length: 408 bp
>T206561 NZ_CP102488:1346414-1346521 [Escherichia coli O15:H18]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9608.98 Da Isoelectric Point: 11.7137
>AT206561 WP_033719712.1 NZ_CP076851:2103443-2103703 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
Download Length: 261 bp
>AT206561 NZ_CP102488:c1346361-1346300 [Escherichia coli O15:H18]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A2ZII2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A2ZI58 |