Detailed information of TA system TA206560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1312789..1313353
• Replicon: chromosome
• Accession: NZ_CP076851
• Organism: Mycobacterium avium subsp. hominissuis strain CAM177

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BB735_RS06570
• Protein ID: WP_084023062.1
• Coordinates: 1312982..1313353 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BB735_RS06565
• Protein ID: WP_011724021.1
• Coordinates: 1312789..1312995 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB735_RS06545 (BB735_006545)	1308069..1309067	+	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
BB735_RS06550 (BB735_006550)	1309091..1310275	-	1185	WP_179294680.1	hypothetical protein	-
BB735_RS06555 (BB735_006555)	1310406..1311479	+	1074	WP_009975391.1	redox-regulated ATPase YchF	-
BB735_RS06560 (BB735_006560)	1311675..1312620	+	946	Protein_1297	HNH endonuclease	-
BB735_RS06565 (BB735_006565)	1312789..1312995	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BB735_RS06570 (BB735_006570)	1312982..1313353	+	372	WP_084023062.1	type II toxin-antitoxin system VapC family toxin	Toxin
BB735_RS06575 (BB735_006575)	1313444..1313893	+	450	WP_024637459.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
BB735_RS06580 (BB735_006580)	1313945..1314220	+	276	WP_084023064.1	hypothetical protein	-
BB735_RS06585 (BB735_006585)	1314322..1314720	+	399	WP_023865349.1	VOC family protein	-
BB735_RS06590 (BB735_006590)	1314789..1315172	+	384	WP_084023066.1	hypothetical protein	-
BB735_RS06595 (BB735_006595)	1315242..1315595	+	354	WP_023865350.1	hypothetical protein	-
BB735_RS06600 (BB735_006600)	1315752..1316300	+	549	WP_080516335.1	glycoside hydrolase	-
BB735_RS06605 (BB735_006605)	1316691..1317014	+	324	WP_044543559.1	putative quinol monooxygenase	-
BB735_RS06610 (BB735_006610)	1317019..1317702	-	684	WP_009975397.1	hypothetical protein	-
BB735_RS06615 (BB735_006615)	1317820..1318017	+	198	WP_009975398.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13653.96 Da
• Isoelectric Point: 6.6025

>T206560 WP_084023062.1 NZ_CP076851:1312982-1313353 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAGVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGAQLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T206560 NZ_CP102488:c1170053-1169877 [Escherichia coli O15:H18]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT206560 WP_011724021.1 NZ_CP076851:1312789-1312995 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT206560 NZ_CP102488:c1169831-1169415 [Escherichia coli O15:H18]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA