Detailed information of TA system TA206559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1086315..1086968
• Replicon: chromosome
• Accession: NZ_CP076851
• Organism: Mycobacterium avium subsp. hominissuis strain CAM177

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: BB735_RS05515
• Protein ID: WP_003872880.1
• Coordinates: 1086507..1086968 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: X7V3T8
• Locus tag: BB735_RS05510
• Protein ID: WP_019733774.1
• Coordinates: 1086315..1086503 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB735_RS05500 (BB735_005500)	1082297..1083883	+	1587	WP_062890673.1	serine hydrolase	-
BB735_RS05505 (BB735_005505)	1083880..1086252	+	2373	WP_095932046.1	cation-translocating P-type ATPase	-
BB735_RS05510 (BB735_005510)	1086315..1086503	+	189	WP_019733774.1	antitoxin	Antitoxin
BB735_RS05515 (BB735_005515)	1086507..1086968	+	462	WP_003872880.1	SRPBCC family protein	Toxin
BB735_RS05520 (BB735_005520)	1087037..1087471	+	435	WP_023900194.1	hypothetical protein	-
BB735_RS05525 (BB735_005525)	1088467..1090050	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
BB735_RS05530 (BB735_005530)	1090090..1090476	+	387	WP_019733869.1	hypothetical protein	-
BB735_RS25415	1090511..1090729	-	219	WP_016705560.1	hypothetical protein	-
BB735_RS25420	1091263..1091601	+	339	WP_009975166.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T206559 WP_003872880.1 NZ_CP076851:1086507-1086968 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T206559 NZ_CP102488:1120574-1120852 [Escherichia coli O15:H18]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6793.46 Da
• Isoelectric Point: 4.4865

>AT206559 WP_019733774.1 NZ_CP076851:1086315-1086503 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKFEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Nucleotide

• Length: 189 bp

>AT206559 NZ_CP102488:1120852-1121136 [Escherichia coli O15:H18]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Structures

Antitoxin

• AlphaFold DB: X7V3T8