Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1747253..1747767 Replicon chromosome
Accession NZ_CP076843
Organism Staphylococcus aureus strain 55-100-003

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KRH49_RS08545 Protein ID WP_000581792.1
Coordinates 1747253..1747462 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KRH49_RS08550 Protein ID WP_000138932.1
Coordinates 1747474..1747767 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRH49_RS08525 (KRH49_08525) 1742764..1744119 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KRH49_RS08530 (KRH49_08530) 1744134..1745204 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KRH49_RS08535 (KRH49_08535) 1745522..1746724 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KRH49_RS08540 (KRH49_08540) 1746988..1747125 - 138 WP_000828354.1 Lmo0850 family protein -
KRH49_RS08545 (KRH49_08545) 1747253..1747462 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KRH49_RS08550 (KRH49_08550) 1747474..1747767 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KRH49_RS08555 (KRH49_08555) 1747933..1749417 + 1485 WP_000571550.1 cardiolipin synthase -
KRH49_RS08560 (KRH49_08560) 1749445..1750092 + 648 WP_001187614.1 HD domain-containing protein -
KRH49_RS13730 1750649..1750711 + 63 Protein_1650 hypothetical protein -
KRH49_RS08570 (KRH49_08570) 1750689..1752004 - 1316 Protein_1651 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T206550 WP_000581792.1 NZ_CP076843:c1747462-1747253 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T206550 NZ_CP102483:2649356-2649673 [Burkholderia contaminans]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACAACCGACGTCTTCGACACCTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCCCGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCGCCGG
TCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGCGCATCTCGACATGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT206550 WP_000138932.1 NZ_CP076843:c1747767-1747474 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT206550 NZ_CP102483:2649677-2649976 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCTTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References