Detailed information of TA system TA206548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1575006..1575782
• Replicon: chromosome
• Accession: NZ_CP076843
• Organism: Staphylococcus aureus strain 55-100-003

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KRH49_RS07585
• Protein ID: WP_000031108.1
• Coordinates: 1575006..1575158 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: KRH49_RS07590
• Protein ID: WP_074371037.1
• Coordinates: 1575183..1575782 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRH49_RS07570 (KRH49_07570)	1571211..1572032	+	822	WP_000669380.1	RluA family pseudouridine synthase	-
KRH49_RS07575 (KRH49_07575)	1572487..1573872	-	1386	WP_000116238.1	class II fumarate hydratase	-
KRH49_RS07580 (KRH49_07580)	1574068..1574463	-	396	WP_000901018.1	hypothetical protein	-
KRH49_RS07585 (KRH49_07585)	1575006..1575158	-	153	WP_000031108.1	SAS053 family protein	Toxin
KRH49_RS07590 (KRH49_07590)	1575183..1575782	-	600	WP_074371037.1	glucosamine-6-phosphate isomerase	Antitoxin
KRH49_RS07595 (KRH49_07595)	1575941..1576411	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KRH49_RS07600 (KRH49_07600)	1576416..1577543	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KRH49_RS07605 (KRH49_07605)	1577694..1578416	-	723	WP_031774878.1	amino acid ABC transporter ATP-binding protein	-
KRH49_RS07610 (KRH49_07610)	1578409..1579866	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T206548 WP_000031108.1 NZ_CP076843:c1575158-1575006 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T206548 NZ_CP102483:c1889109-1888813 [Burkholderia contaminans]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGTCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAACTCGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGAGCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGACCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22355.53 Da
• Isoelectric Point: 5.1445

>AT206548 WP_074371037.1 NZ_CP076843:c1575782-1575183 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLILQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT206548 NZ_CP102483:c1888810-1888409 [Burkholderia contaminans]
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTCGTCCGCGGCACGCGAGACATCCCATATACCTACAAGGGCCGGTCGAC
TGTCGTTCGCGACATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCACGGAATTCAACAAGCAGGTGAACGCCACCCTCGTCGACCCGAAGTACATCGCCAAGGTGCGCAAGAAG
CTGAAGCTGGATCAGCGCGAGGCGGCCGAGCTCTTCGGCGGCGGCGTCAACGCATTCTCCCGTTACGAAACGGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAATTGCTGAAGCTCCTGGATCGTCACCCCGATCTGCTCGCCGAAGTGCGAGCAGCAT
AG

Structures

Toxin

• AlphaFold DB: X5E2E6