Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 1361872..1362980 | Replicon | chromosome |
| Accession | NZ_CP076843 | ||
| Organism | Staphylococcus aureus strain 55-100-003 | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | A0A0M4MHJ8 |
| Locus tag | KRH49_RS06565 | Protein ID | WP_002303392.1 |
| Coordinates | 1361872..1362741 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | B9DSK1 |
| Locus tag | KRH49_RS06570 | Protein ID | WP_002303393.1 |
| Coordinates | 1362756..1362980 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KRH49_RS06520 (KRH49_06520) | 1356967..1357275 | - | 309 | WP_000457386.1 | 50S ribosomal protein L21 | - |
| KRH49_RS06525 (KRH49_06525) | 1357762..1358292 | - | 531 | WP_001259929.1 | rod shape-determining protein MreD | - |
| KRH49_RS06530 (KRH49_06530) | 1358292..1359134 | - | 843 | WP_000911033.1 | rod shape-determining protein MreC | - |
| KRH49_RS06535 (KRH49_06535) | 1359332..1359451 | - | 120 | WP_000840603.1 | hypothetical protein | - |
| KRH49_RS06540 (KRH49_06540) | 1359525..1359998 | - | 474 | WP_001236734.1 | DUF4930 family protein | - |
| KRH49_RS06545 (KRH49_06545) | 1360158..1360355 | + | 198 | WP_000025835.1 | hypothetical protein | - |
| KRH49_RS06550 (KRH49_06550) | 1360472..1360756 | - | 285 | WP_000171859.1 | hypothetical protein | - |
| KRH49_RS06555 (KRH49_06555) | 1360824..1360970 | - | 147 | Protein_1291 | hypothetical protein | - |
| KRH49_RS06560 (KRH49_06560) | 1361205..1361891 | - | 687 | WP_224103254.1 | class I SAM-dependent methyltransferase | - |
| KRH49_RS06565 (KRH49_06565) | 1361872..1362741 | - | 870 | WP_002303392.1 | nucleotidyltransferase domain-containing protein | Toxin |
| KRH49_RS06570 (KRH49_06570) | 1362756..1362980 | - | 225 | WP_002303393.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KRH49_RS06575 (KRH49_06575) | 1363123..1363944 | - | 822 | Protein_1295 | recombinase family protein | - |
| KRH49_RS06580 (KRH49_06580) | 1364632..1365435 | - | 804 | WP_002294514.1 | lincosamide nucleotidyltransferase Lnu(B) | - |
| KRH49_RS06585 (KRH49_06585) | 1365489..1366973 | - | 1485 | WP_074371031.1 | ABC-F type ribosomal protection protein Lsa(E) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | lnu(B) / lsa(E) | - | 1360472..1368861 | 8389 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32807.38 Da Isoelectric Point: 4.7269
>T206547 WP_002303392.1 NZ_CP076843:c1362741-1361872 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
>T206547 NZ_CP102483:1789292-1789708 [Burkholderia contaminans]
GTGTATTTGATTGACACGAATATCATCAGCGAAATCAGGAGGGGCAAGCGAACCAACCGTGGCGTGCGGGCGTTTTTCAG
GCAGGTCGCGGCGGACGCAAGCCCGCTTTATCTTTCCGTCGTAACGGTTGCTGAACTTCGCCGCGGCGTCGATCTGATCC
GTCATCGCGGCGATCATGCTCAGGCGTCGGCGCTCGAGGCCTGGATGGCGACGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGACATCGAGATCAGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTGGTCACGCGCAACGTCGCGGATTTCGCCCGCACCGGCGTCAAGCTGC
TGAACCCGTTCGACTGA
GTGTATTTGATTGACACGAATATCATCAGCGAAATCAGGAGGGGCAAGCGAACCAACCGTGGCGTGCGGGCGTTTTTCAG
GCAGGTCGCGGCGGACGCAAGCCCGCTTTATCTTTCCGTCGTAACGGTTGCTGAACTTCGCCGCGGCGTCGATCTGATCC
GTCATCGCGGCGATCATGCTCAGGCGTCGGCGCTCGAGGCCTGGATGGCGACGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGACATCGAGATCAGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTGGTCACGCGCAACGTCGCGGATTTCGCCCGCACCGGCGTCAAGCTGC
TGAACCCGTTCGACTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8351.65 Da Isoelectric Point: 4.5357
>AT206547 WP_002303393.1 NZ_CP076843:c1362980-1362756 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE
Download Length: 225 bp
>AT206547 NZ_CP102483:1789069-1789305 [Burkholderia contaminans]
ATGGCAAATCTACTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCAAATGGCAGGAG
TGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGGAAGACATTTGCGCAAGTGCTGATGA
GCATGCCCGATGTTGGCGACGACGCGGATTTTCAACGTGTTCAGGATTCCGGCGAGGCCAGGCGTGTATTTGATTGA
ATGGCAAATCTACTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCAAATGGCAGGAG
TGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGGAAGACATTTGCGCAAGTGCTGATGA
GCATGCCCGATGTTGGCGACGACGCGGATTTTCAACGTGTTCAGGATTCCGGCGAGGCCAGGCGTGTATTTGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M4MHJ8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M5SHM7 |