Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 522223..522699 Replicon chromosome
Accession NZ_CP076843
Organism Staphylococcus aureus strain 55-100-003

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KRH49_RS02555 Protein ID WP_000052076.1
Coordinates 522223..522411 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KRH49_RS02560 Protein ID WP_001059690.1
Coordinates 522439..522699 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRH49_RS02525 (KRH49_02525) 518252..518734 + 483 WP_000824489.1 hypothetical protein -
KRH49_RS02530 (KRH49_02530) 519075..519761 + 687 WP_001574556.1 thermonuclease family protein -
KRH49_RS02535 (KRH49_02535) 520118..520318 + 201 WP_001059082.1 cold-shock protein -
KRH49_RS02540 (KRH49_02540) 520815..521033 - 219 WP_000005881.1 hypothetical protein -
KRH49_RS02545 (KRH49_02545) 521094..521378 - 285 WP_001004403.1 hypothetical protein -
KRH49_RS02550 (KRH49_02550) 521466..522035 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
KRH49_RS02555 (KRH49_02555) 522223..522411 - 189 WP_000052076.1 hypothetical protein Toxin
KRH49_RS02560 (KRH49_02560) 522439..522699 - 261 WP_001059690.1 hypothetical protein Antitoxin
KRH49_RS02565 (KRH49_02565) 523041..523244 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KRH49_RS02570 (KRH49_02570) 523241..523477 - 237 WP_000368687.1 hypothetical protein -
KRH49_RS02575 (KRH49_02575) 523702..524283 + 582 WP_001140696.1 histidine phosphatase family protein -
KRH49_RS02580 (KRH49_02580) 524356..524973 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
KRH49_RS02585 (KRH49_02585) 525122..525616 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
KRH49_RS02590 (KRH49_02590) 526015..526437 - 423 WP_074371006.1 organic hydroperoxide resistance protein -
KRH49_RS02595 (KRH49_02595) 526585..527301 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T206546 WP_000052076.1 NZ_CP076843:c522411-522223 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T206546 NZ_CP102483:1535661-1536557 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGGGCTGCTCGGGCAGTTCCCCGAACGGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCAGCATGCTGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTTCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGTGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCGGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCCACCGATCTCGCCGGCTTTCGCGGCCGCACGGCTGTGGCGGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCAGGCCATGCCGGCTACGTGGAGGCACCGGCCGTCTATTCCGCGCTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT206546 WP_001059690.1 NZ_CP076843:c522699-522439 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT206546 NZ_CP102483:1536554-1537411 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACAACCCGAATCCGAAAACGGCAAGGCCGAAGCCGGCTACGTGGTCCCCGGTCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGGTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGTGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGCGCTGAACCGCATGACGAACGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACACAGAGGATCGTTGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCTTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References