Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2790944..2791741 | Replicon | chromosome |
| Accession | NZ_CP076839 | ||
| Organism | Staphylococcus aureus strain 55-100-016 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | KRH48_RS13545 | Protein ID | WP_000525004.1 |
| Coordinates | 2790944..2791405 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | KRH48_RS13550 | Protein ID | WP_001260485.1 |
| Coordinates | 2791418..2791741 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KRH48_RS13520 (KRH48_13520) | 2785954..2787981 | + | 2028 | WP_014532489.1 | hypothetical protein | - |
| KRH48_RS13525 (KRH48_13525) | 2788024..2789229 | - | 1206 | WP_031585161.1 | tyrosine-type recombinase/integrase | - |
| KRH48_RS13530 (KRH48_13530) | 2789355..2789969 | + | 615 | WP_031863779.1 | hypothetical protein | - |
| KRH48_RS13535 (KRH48_13535) | 2789966..2790112 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| KRH48_RS13540 (KRH48_13540) | 2790342..2790926 | - | 585 | WP_000825948.1 | hypothetical protein | - |
| KRH48_RS13545 (KRH48_13545) | 2790944..2791405 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| KRH48_RS13550 (KRH48_13550) | 2791418..2791741 | - | 324 | WP_001260485.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KRH48_RS13555 (KRH48_13555) | 2791905..2792153 | + | 249 | WP_000272860.1 | helix-turn-helix transcriptional regulator | - |
| KRH48_RS13560 (KRH48_13560) | 2792169..2792312 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| KRH48_RS13565 (KRH48_13565) | 2792302..2792511 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| KRH48_RS13570 (KRH48_13570) | 2792567..2792812 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| KRH48_RS13575 (KRH48_13575) | 2792781..2793146 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| KRH48_RS13580 (KRH48_13580) | 2793201..2793416 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| KRH48_RS13585 (KRH48_13585) | 2793441..2793704 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| KRH48_RS13590 (KRH48_13590) | 2793717..2793878 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| KRH48_RS13595 (KRH48_13595) | 2793957..2794280 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| KRH48_RS13600 (KRH48_13600) | 2794295..2794657 | + | 363 | WP_031863778.1 | hypothetical protein | - |
| KRH48_RS13605 (KRH48_13605) | 2794654..2795820 | + | 1167 | WP_031863777.1 | DUF2800 domain-containing protein | - |
| KRH48_RS13610 (KRH48_13610) | 2795846..2796403 | + | 558 | WP_000645045.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2785032..2809427 | 24395 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T206542 WP_000525004.1 NZ_CP076839:c2791405-2790944 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T206542 NZ_CP102483:c87127-86747 [Burkholderia contaminans]
ATGAATGTGCTGATCGATACGTCTGTCTGGGTTGATCACTTCCGAAACAGGAATCAGACGTTGTTCGGGTTGCTCGCACT
CGACGCAGTGCTGATGCATCCGATGGTGCTTGGCGAGCTCGCGTGCGGGACGCCGCCGGCGCCGCGGCTGCGAACGTTGA
GCGACCTTGGACTACTCCAGGAATGCAATCAGGCCAGCATGCGTGAAGTAATGGCATTCGTGGAGCGCGAGAGCCTTTAC
GGTATGGGTTATGGTCTTGTCGATCTGACCTTGTTGGCGTCGACGCTGATCACGCCGGGCGCGCGCTTCTGGACCCTGGA
TCGACGTCTGGCTGCCTTGGCGGATCGTTTTTCAGTCGCATTCCGCTCGACTTCAGCGTGA
ATGAATGTGCTGATCGATACGTCTGTCTGGGTTGATCACTTCCGAAACAGGAATCAGACGTTGTTCGGGTTGCTCGCACT
CGACGCAGTGCTGATGCATCCGATGGTGCTTGGCGAGCTCGCGTGCGGGACGCCGCCGGCGCCGCGGCTGCGAACGTTGA
GCGACCTTGGACTACTCCAGGAATGCAATCAGGCCAGCATGCGTGAAGTAATGGCATTCGTGGAGCGCGAGAGCCTTTAC
GGTATGGGTTATGGTCTTGTCGATCTGACCTTGTTGGCGTCGACGCTGATCACGCCGGGCGCGCGCTTCTGGACCCTGGA
TCGACGTCTGGCTGCCTTGGCGGATCGTTTTTCAGTCGCATTCCGCTCGACTTCAGCGTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT206542 WP_001260485.1 NZ_CP076839:c2791741-2791418 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT206542 NZ_CP102483:c87330-87124 [Burkholderia contaminans]
ATGCGAACCACGGTGACTATCGACGACGATCTCTACACAAAGGCTCTGCAAATGGCCGAACCCGGGATGGACAAGGCGGA
CTTGTTTCGTGAGGCAATCAAGACGTTTGTGCGTGTCCAGGCCGCCAAACGCCTGGCCGCACTCGGCGGAACCATGTCTG
ACATGGCTGATATCCCGCGACGCCGCCAAGAGCCGGAATCGCAATGA
ATGCGAACCACGGTGACTATCGACGACGATCTCTACACAAAGGCTCTGCAAATGGCCGAACCCGGGATGGACAAGGCGGA
CTTGTTTCGTGAGGCAATCAAGACGTTTGTGCGTGTCCAGGCCGCCAAACGCCTGGCCGCACTCGGCGGAACCATGTCTG
ACATGGCTGATATCCCGCGACGCCGCCAAGAGCCGGAATCGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|