206541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 2630900..2632008 Replicon chromosome
Accession NZ_CP076839
Organism Staphylococcus aureus strain 55-100-016

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag KRH48_RS12680 Protein ID WP_002303392.1
Coordinates 2631139..2632008 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag KRH48_RS12675 Protein ID WP_002303393.1
Coordinates 2630900..2631124 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRH48_RS12660 (KRH48_12660) 2626907..2628391 + 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
KRH48_RS12665 (KRH48_12665) 2628445..2629248 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
KRH48_RS12670 (KRH48_12670) 2629936..2630757 + 822 Protein_2472 recombinase family protein -
KRH48_RS12675 (KRH48_12675) 2630900..2631124 + 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
KRH48_RS12680 (KRH48_12680) 2631139..2632008 + 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
KRH48_RS12685 (KRH48_12685) 2631989..2632675 + 687 WP_224103254.1 class I SAM-dependent methyltransferase -
KRH48_RS12690 (KRH48_12690) 2632905..2633057 + 153 Protein_2476 hypothetical protein -
KRH48_RS12695 (KRH48_12695) 2633125..2633409 + 285 WP_000171859.1 hypothetical protein -
KRH48_RS12700 (KRH48_12700) 2633526..2633723 - 198 WP_000041095.1 hypothetical protein -
KRH48_RS12705 (KRH48_12705) 2633883..2634356 + 474 WP_001236734.1 DUF4930 family protein -
KRH48_RS12710 (KRH48_12710) 2634430..2634549 + 120 WP_000840603.1 hypothetical protein -
KRH48_RS12715 (KRH48_12715) 2634747..2635589 + 843 WP_000911033.1 rod shape-determining protein MreC -
KRH48_RS12720 (KRH48_12720) 2635589..2636119 + 531 WP_001259929.1 rod shape-determining protein MreD -
KRH48_RS12725 (KRH48_12725) 2636606..2636914 + 309 WP_000457386.1 50S ribosomal protein L21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island lsa(E) / lnu(B) - 2625360..2634356 8996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T206541 WP_002303392.1 NZ_CP076839:2631139-2632008 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T206541 NZ_CP102482:c3740053-3739778 [Burkholderia contaminans]
ATGCTGCCCGTTGAGTGGCGGCCCCGGGCGCGGTTCAGGTTGCACAAAATCCTGTCGGACATCGCTGAACTGAACGTGTT
CGCAGCCGACGACCTGGCGAACGACATCGAGCAAGCCACCTCGAACCTGCCCGCGCACCCGTACCTGTACCGCCTGGGCC
GAGTCGCCGGCACCCGCGAAATCGTGGTCCATCCGAACTACATCGTCATCTACCGTGTTTGCCCTGCGTTCATCGAAGTC
GTGAACGTGGTGCACGCCCGGCAACAGTACCCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT206541 WP_002303393.1 NZ_CP076839:2630900-2631124 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT206541 NZ_CP102482:c3740231-3740040 [Burkholderia contaminans]
ATGAACGCCATCCTTTCTCCCATCGAATCAGAGTTCACCACGGCCGAGGAGGCCGAGGCGTACGACCGCTGGCTTCGTGC
GGAAGTCCAGGCGTCGCTCGACGATCCGGCCCCGAATATCCCGCACGACGAGGTGATGGGCGACGTGCGCGCCATGCTGG
CCGAACGAAAGGCCCGCAATGCTGCCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References