Detailed information of TA system TA206540

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2418135..2418911
• Replicon: chromosome
• Accession: NZ_CP076839
• Organism: Staphylococcus aureus strain 55-100-016

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KRH48_RS11665
• Protein ID: WP_000031108.1
• Coordinates: 2418759..2418911 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KRH48_RS11660
• Protein ID: WP_001251224.1
• Coordinates: 2418135..2418734 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRH48_RS11640 (KRH48_11640)	2414051..2415508	+	1458	WP_000649908.1	ABC transporter permease subunit	-
KRH48_RS11645 (KRH48_11645)	2415501..2416223	+	723	WP_031774878.1	amino acid ABC transporter ATP-binding protein	-
KRH48_RS11650 (KRH48_11650)	2416374..2417501	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KRH48_RS11655 (KRH48_11655)	2417506..2417976	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KRH48_RS11660 (KRH48_11660)	2418135..2418734	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KRH48_RS11665 (KRH48_11665)	2418759..2418911	+	153	WP_000031108.1	SAS053 family protein	Toxin
KRH48_RS11670 (KRH48_11670)	2419454..2419849	+	396	WP_000901018.1	hypothetical protein	-
KRH48_RS11675 (KRH48_11675)	2420045..2421430	+	1386	WP_000116238.1	class II fumarate hydratase	-
KRH48_RS11680 (KRH48_11680)	2421885..2422706	-	822	WP_000669380.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T206540 WP_000031108.1 NZ_CP076839:2418759-2418911 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T206540 NZ_CP102482:1968641-1969057 [Burkholderia contaminans]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCCGATCTCGCCGCGCGCGGCATGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAGTTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCAGCCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT206540 WP_001251224.1 NZ_CP076839:2418135-2418734 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT206540 NZ_CP102482:1968384-1968644 [Burkholderia contaminans]
ATGCGCACCGTTTCCATTTTCAAGAACGCACGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGGCCCGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4