Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2237357..2237871 Replicon chromosome
Accession NZ_CP076839
Organism Staphylococcus aureus strain 55-100-016

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KRH48_RS10655 Protein ID WP_000581792.1
Coordinates 2237662..2237871 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KRH48_RS10650 Protein ID WP_000138932.1
Coordinates 2237357..2237650 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRH48_RS10630 (KRH48_10630) 2233120..2234435 + 1316 Protein_2106 ISL3 family transposase -
KRH48_RS13970 2234413..2234475 - 63 Protein_2107 hypothetical protein -
KRH48_RS10640 (KRH48_10640) 2235032..2235679 - 648 WP_001187614.1 HD domain-containing protein -
KRH48_RS10645 (KRH48_10645) 2235707..2237191 - 1485 WP_000571550.1 cardiolipin synthase -
KRH48_RS10650 (KRH48_10650) 2237357..2237650 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KRH48_RS10655 (KRH48_10655) 2237662..2237871 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KRH48_RS10660 (KRH48_10660) 2237999..2238136 + 138 WP_000828354.1 Lmo0850 family protein -
KRH48_RS10665 (KRH48_10665) 2238400..2239602 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KRH48_RS10670 (KRH48_10670) 2239920..2240990 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KRH48_RS10675 (KRH48_10675) 2241005..2242360 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T206538 WP_000581792.1 NZ_CP076839:2237662-2237871 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T206538 NZ_CP102480:3679281-3679535 [Nisaea acidiphila]
ATGCGCACCAAATCCTACAGCGACCTCCGGCGAAACCTCGCGGCCACGCTCGACAGCGTGACGGCGGATCATGAGCCGGT
GATCATCACGCGGGACCGGGGCAAGCCGGCGGCCGTGCTGATGTCGCTTGAGGATTTCGCCTCCTACGAGGAAACCCGCT
ACCTGCTGCGCAGCCCGGAGAATGCGGACCGGCTGATCGAGGCGGTGAGCGCGCTCGAAGCCGGGGCCGGACGGGAAGAA
CAGCTCGAGGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT206538 WP_000138932.1 NZ_CP076839:2237357-2237650 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT206538 NZ_CP102480:3679532-3679786 [Nisaea acidiphila]
ATGAAGCTCGTCTTCCACGAGCGGGCCTGGGAGGACTACCTCCATTGGCAGAAGACGGACCGGAAGCTGCATCAGCGTCT
GAATGCCCTGATCCGCGAATGCACGCGGACGCCCTTCGAGGGGACCGGCAAGCCGGAACCTTTGCGGGGGCCGCTCTCCG
GCTGGTGGTCGCGGCGGCTGACGCTGGAGCACCGGCTGGTCTACCGCGTCCACGAGGACCAGCTGCAGATCGCGCAGTGC
CGGTATCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References