Detailed information of TA system TA206531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 699116..699592
• Replicon: chromosome
• Accession: NZ_CP076839
• Organism: Staphylococcus aureus strain 55-100-016

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KRH48_RS03270
• Protein ID: WP_000052076.1
• Coordinates: 699404..699592 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KRH48_RS03265
• Protein ID: WP_001059690.1
• Coordinates: 699116..699376 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRH48_RS03230 (KRH48_03230)	694514..695230	-	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-
KRH48_RS03235 (KRH48_03235)	695378..695800	+	423	WP_000974452.1	organic hydroperoxide resistance protein	-
KRH48_RS03240 (KRH48_03240)	696199..696693	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KRH48_RS03245 (KRH48_03245)	696842..697459	+	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
KRH48_RS03250 (KRH48_03250)	697532..698113	-	582	WP_001140696.1	histidine phosphatase family protein	-
KRH48_RS03255 (KRH48_03255)	698338..698574	+	237	WP_000368687.1	hypothetical protein	-
KRH48_RS03260 (KRH48_03260)	698571..698774	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KRH48_RS03265 (KRH48_03265)	699116..699376	+	261	WP_001059690.1	hypothetical protein	Antitoxin
KRH48_RS03270 (KRH48_03270)	699404..699592	+	189	WP_000052076.1	hypothetical protein	Toxin
KRH48_RS03275 (KRH48_03275)	699780..700349	+	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
KRH48_RS03280 (KRH48_03280)	700437..700721	+	285	WP_001004403.1	hypothetical protein	-
KRH48_RS03285 (KRH48_03285)	700782..701000	+	219	WP_000005881.1	hypothetical protein	-
KRH48_RS03290 (KRH48_03290)	701497..701697	-	201	WP_001059082.1	cold-shock protein	-
KRH48_RS03295 (KRH48_03295)	702054..702740	-	687	WP_001574556.1	thermonuclease family protein	-
KRH48_RS03300 (KRH48_03300)	703081..703563	-	483	WP_000824489.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T206531 WP_000052076.1 NZ_CP076839:699404-699592 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T206531 NZ_CP102479:870951-871361 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT206531 WP_001059690.1 NZ_CP076839:699116-699376 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT206531 NZ_CP102479:870704-870970 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATACGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56