Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3201220..3201839 Replicon chromosome
Accession NZ_CP076838
Organism Leclercia pneumoniae strain 49125

Toxin (Protein)


Gene name Hha Uniprot ID A0A0M3F8Q9
Locus tag KQ929_RS15775 Protein ID WP_040076875.1
Coordinates 3201621..3201839 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0M3F8E5
Locus tag KQ929_RS15770 Protein ID WP_046884434.1
Coordinates 3201220..3201612 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ929_RS15760 (KQ929_15760) 3196814..3199951 + 3138 WP_040076873.1 multidrug efflux RND transporter permease subunit AcrB -
KQ929_RS15770 (KQ929_15770) 3201220..3201612 + 393 WP_046884434.1 Hha toxicity modulator TomB Antitoxin
KQ929_RS15775 (KQ929_15775) 3201621..3201839 + 219 WP_040076875.1 HHA domain-containing protein Toxin
KQ929_RS15780 (KQ929_15780) 3202114..3202578 + 465 WP_040076876.1 YlaC family protein -
KQ929_RS15785 (KQ929_15785) 3202650..3202790 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KQ929_RS15790 (KQ929_15790) 3202793..3203053 - 261 WP_046884436.1 type B 50S ribosomal protein L31 -
KQ929_RS15795 (KQ929_15795) 3203273..3204832 + 1560 WP_207293121.1 EAL domain-containing protein -
KQ929_RS15800 (KQ929_15800) 3204875..3205229 - 355 Protein_3077 DUF1428 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T206528 WP_040076875.1 NZ_CP076838:3201621-3201839 [Leclercia pneumoniae]
MSEKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T206528 NZ_CP102476:2590964-2591263 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15156.96 Da        Isoelectric Point: 5.1531

>AT206528 WP_046884434.1 NZ_CP076838:3201220-3201612 [Leclercia pneumoniae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDDSNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINSQDLQKWRKSGNRLFRCFVNASRANPLGSYVKTITNN

Download         Length: 393 bp

>AT206528 NZ_CP102476:2590655-2590960 [Burkholderia cenocepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCG
CATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCGTCGTCGAAATGC
GTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGAACGATATGGGTCATCCTGCTCTGCGGCGGCGAT
AAATCGGCGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3F8Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M3F8E5

References