Detailed information of TA system TA206527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1999124..2000727
• Replicon: chromosome
• Accession: NZ_CP076838
• Organism: Leclercia pneumoniae strain 49125

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KQ929_RS09840
• Protein ID: WP_207291736.1
• Coordinates: 1999393..2000727 (+)
• Length: 445 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KQ929_RS09835
• Protein ID: WP_207291737.1
• Coordinates: 1999124..1999393 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ929_RS09820 (KQ929_09820)	1994433..1995530	-	1098	WP_207291740.1	NADH:flavin oxidoreductase	-
KQ929_RS09825 (KQ929_09825)	1995651..1996538	+	888	WP_207291739.1	LysR family transcriptional regulator	-
KQ929_RS09830 (KQ929_09830)	1996803..1998992	+	2190	WP_207291738.1	TonB-dependent siderophore receptor	-
KQ929_RS09835 (KQ929_09835)	1999124..1999393	+	270	WP_207291737.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KQ929_RS09840 (KQ929_09840)	1999393..2000727	+	1335	WP_207291736.1	type II toxin-antitoxin system HipA family toxin	Toxin
KQ929_RS09845 (KQ929_09845)	2000966..2002108	+	1143	WP_207291735.1	class C beta-lactamase	-
KQ929_RS09850 (KQ929_09850)	2002141..2002512	-	372	WP_040075696.1	cupin domain-containing protein	-
KQ929_RS09855 (KQ929_09855)	2002670..2003563	+	894	WP_207291734.1	siderophore-interacting protein	-
KQ929_RS09860 (KQ929_09860)	2003627..2003986	+	360	WP_207291733.1	nuclear transport factor 2 family protein	-
KQ929_RS09865 (KQ929_09865)	2004090..2004416	+	327	WP_040075693.1	YebG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 445 a.a.
• Molecular weight: 49708.31 Da
• Isoelectric Point: 9.1219

>T206527 WP_207291736.1 NZ_CP076838:1999393-2000727 [Leclercia pneumoniae]
MPKLVTWMNNERVGELTKLPNGAHTFKYDREWLYNRHARPISLSLPLQTGTLTSDAVFNFFDNLLPDSAVVRDRIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPDAIISAPIMRWETLDEPRLEKVLSAYQADIPLGMIKDENDFRISVAGAQEKTAL
LQINDAWCIPKGITPTNHIIKLPIGEIRQPNATLDLRDSVDNEYFCLAFARALGLAVPDATIITAGQIRALAVERFDRRW
NADRTMLLRLPQEDMCQAFGLPSSLKYESDGGPGILPIMSFLLGSSEALQDRYHFMQFQLFQWLLAATDGHAKNFSVFIQ
PGGSYRLTPFYDILSAYPLLGGAGLHISDLKLAMGLKASRGRKNAIDRIYPRHFFALAKEVGFAQSEMERIMQTFAQQVP
DALRRVNDALPAGFSSRVAKTITAGVLRLHQRLVNGLSLTGYKY

Nucleotide

• Length: 1335 bp

>T206527 NZ_CP102476:2590655-2590960 [Burkholderia cenocepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCG
CATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCGTCGTCGAAATGC
GTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGAACGATATGGGTCATCCTGCTCTGCGGCGGCGAT
AAATCGGCGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10317.78 Da
• Isoelectric Point: 5.7832

>AT206527 WP_207291737.1 NZ_CP076838:1999124-1999393 [Leclercia pneumoniae]
MKPPMIYSPVQLANYLKLTRQKNNWTQSELARKIGIKQATVSNFENNPDNITLTTFFKLLQALELTMVLYDKGETVEDST
SIQHQDVEW

Nucleotide

• Length: 270 bp

>AT206527 NZ_CP102476:2590964-2591263 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA