Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1991815..1992581 Replicon chromosome
Accession NZ_CP076838
Organism Leclercia pneumoniae strain 49125

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KQ929_RS09800 Protein ID WP_207291744.1
Coordinates 1991815..1992306 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag KQ929_RS09805 Protein ID WP_207291743.1
Coordinates 1992294..1992581 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ929_RS09775 (KQ929_09775) 1987991..1989112 + 1122 WP_207291748.1 porin OmpC -
KQ929_RS09780 (KQ929_09780) 1989119..1989877 - 759 WP_207291747.1 trans-aconitate 2-methyltransferase -
KQ929_RS09785 (KQ929_09785) 1989951..1990313 - 363 WP_207291746.1 DUF4406 domain-containing protein -
KQ929_RS09790 (KQ929_09790) 1990321..1990905 - 585 WP_040075708.1 GDP-mannose pyrophosphatase -
KQ929_RS09795 (KQ929_09795) 1990993..1991748 + 756 WP_207291745.1 DeoR/GlpR family DNA-binding transcription regulator -
KQ929_RS09800 (KQ929_09800) 1991815..1992306 - 492 WP_207291744.1 GNAT family N-acetyltransferase Toxin
KQ929_RS09805 (KQ929_09805) 1992294..1992581 - 288 WP_207291743.1 DUF1778 domain-containing protein Antitoxin
KQ929_RS09810 (KQ929_09810) 1992749..1993897 - 1149 WP_207291742.1 PD-(D/E)XK nuclease family protein -
KQ929_RS09815 (KQ929_09815) 1994061..1994399 + 339 WP_207291741.1 hypothetical protein -
KQ929_RS09820 (KQ929_09820) 1994433..1995530 - 1098 WP_207291740.1 NADH:flavin oxidoreductase -
KQ929_RS09825 (KQ929_09825) 1995651..1996538 + 888 WP_207291739.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(6-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17699.52 Da        Isoelectric Point: 9.8614

>T206526 WP_207291744.1 NZ_CP076838:c1992306-1991815 [Leclercia pneumoniae]
VGKVTAPVPLNSSHILAEFHCGEAALDEWIKHRGLKNQSMGAARTFVVCRGNASQVIGFYSLATGSVTHAVAPGSLRRNM
PDPVPVIILARLAVDASFHSKGLGADLLHDAVLRCCRVAENIGVRAIMVHAISDRARQFYIHHGFTPSQTQERTLFLRLP
IIT

Download         Length: 492 bp

>T206526 NZ_CP102476:c2185848-2185441 [Burkholderia cenocepacia]
ATGAAGTTCCTGCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATCCCCGCGATCGTCGCGCACGCGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCGG
CGAACGTCGCGCGTGTCGAGGCGTTGCAGTTCGAGGTCGTATCATTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGCGCGCACCTGATCGCGGCCGGCACGCCGATTGGTCCATACGACGCCTTGATCGCAGGGCAGGCGCGCGCGCGGCAACT
GGTGCTGGTCACGCACAACGTCCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTAGCCGAACCGAGCG
CAGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10855.56 Da        Isoelectric Point: 5.1530

>AT206526 WP_207291743.1 NZ_CP076838:c1992581-1992294 [Leclercia pneumoniae]
MLYKGGSMKSDVQLNIRAKEAQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIEMLDAPVTAN
PAMDKLLARKPQWEK

Download         Length: 288 bp

>AT206526 NZ_CP102476:c2186087-2185845 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGCGGCTCGCAGGCTGTCCGGCTGCCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCGGTGGACGCCGATTTCGAGGCTGCCGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References