Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 707158..707821 Replicon chromosome
Accession NZ_CP076838
Organism Leclercia pneumoniae strain 49125

Toxin (Protein)


Gene name cptA Uniprot ID A0A0M3EX34
Locus tag KQ929_RS03510 Protein ID WP_046887112.1
Coordinates 707405..707821 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0M3EXE7
Locus tag KQ929_RS03505 Protein ID WP_040074142.1
Coordinates 707158..707424 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ929_RS03480 (KQ929_03480) 702333..703766 - 1434 WP_207292360.1 6-phospho-beta-glucosidase -
KQ929_RS03485 (KQ929_03485) 703882..704613 - 732 WP_046887115.1 MurR/RpiR family transcriptional regulator -
KQ929_RS03490 (KQ929_03490) 704666..704977 + 312 WP_040074139.1 N(4)-acetylcytidine aminohydrolase -
KQ929_RS03495 (KQ929_03495) 705142..705801 + 660 WP_040074140.1 hemolysin III family protein -
KQ929_RS03500 (KQ929_03500) 705886..706866 - 981 WP_207292359.1 tRNA-modifying protein YgfZ -
KQ929_RS03505 (KQ929_03505) 707158..707424 + 267 WP_040074142.1 FAD assembly factor SdhE Antitoxin
KQ929_RS03510 (KQ929_03510) 707405..707821 + 417 WP_046887112.1 protein YgfX Toxin
KQ929_RS03515 (KQ929_03515) 707826..708347 - 522 WP_207292358.1 flavodoxin FldB -
KQ929_RS03520 (KQ929_03520) 708450..709346 + 897 WP_207292357.1 site-specific tyrosine recombinase XerD -
KQ929_RS03525 (KQ929_03525) 709372..710085 + 714 WP_040074147.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KQ929_RS03530 (KQ929_03530) 710091..711824 + 1734 WP_207292356.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16340.10 Da        Isoelectric Point: 10.7427

>T206517 WP_046887112.1 NZ_CP076838:707405-707821 [Leclercia pneumoniae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAAILLMPWPLSYTPLWLLLLSLVVFDSVRSQRRINARQGEIKLFMDSRLRWQGK
EWEIVGSPWMINAGMMLRLRASEEQRCHHLWVSADSMDEGEWRDLRRMIAQQQPTQGR

Download         Length: 417 bp

>T206517 NZ_CP102473:774421-774720 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10516.99 Da        Isoelectric Point: 4.6761

>AT206517 WP_040074142.1 NZ_CP076838:707158-707424 [Leclercia pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEDKQLFIRLLECDDPDLFNWLMNHGEPADSELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206517 NZ_CP102473:774100-774417 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTATTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3EX34

Antitoxin

Source ID Structure
AlphaFold DB A0A0M3EXE7

References