Detailed information of TA system TA206515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): virAT/YafQ(toxin)
• Location: 30271..30814
• Replicon: plasmid pVir
• Accession: NZ_CP076837
• Organism: Campylobacter jejuni X voucher NCTC 13357

Toxin (Protein)

• Gene name: virT
• Uniprot ID: -
• Locus tag: N578_RS09455
• Protein ID: WP_053868684.1
• Coordinates: 30545..30814 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: virA
• Uniprot ID: A0A5T1CFM5
• Locus tag: N578_RS09450
• Protein ID: WP_053868685.1
• Coordinates: 30271..30555 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N578_RS09405 (N578_09405)	25883..26227	+	345	WP_024266121.1	hypothetical protein	-
N578_RS09410 (N578_09410)	26241..26549	+	309	WP_011117580.1	hypothetical protein	-
N578_RS09415 (N578_09415)	26559..26780	+	222	WP_011799395.1	hypothetical protein	-
N578_RS09420 (N578_09420)	27258..27755	+	498	WP_024266124.1	hypothetical protein	-
N578_RS09425 (N578_09425)	27850..28284	+	435	WP_115614173.1	hypothetical protein	-
N578_RS09430 (N578_09430)	28271..28702	+	432	WP_021357906.1	hypothetical protein	-
N578_RS09435 (N578_09435)	28702..29004	+	303	WP_024266116.1	hypothetical protein	-
N578_RS09440 (N578_09440)	29193..29561	+	369	WP_115614174.1	hypothetical protein	-
N578_RS09445 (N578_09445)	29676..30047	+	372	WP_052835040.1	hypothetical protein	-
N578_RS09450 (N578_09450)	30271..30555	+	285	WP_053868685.1	hypothetical protein	Antitoxin
N578_RS09455 (N578_09455)	30545..30814	+	270	WP_053868684.1	type II toxin-antitoxin system YafQ family toxin	Toxin
N578_RS09460 (N578_09460)	30928..31239	+	312	Protein_42	hypothetical protein	-
N578_RS09465 (N578_09465)	31547..33118	-	1572	WP_115614176.1	relaxase/mobilization nuclease domain-containing protein	-
N578_RS09470 (N578_09470)	33991..34296	+	306	WP_011799398.1	hypothetical protein	-
N578_RS09475 (N578_09475)	34296..34538	+	243	WP_052835045.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	virB4 / Cjp54 / virB8 / virB9 / virB10 / virB11 / virD4	1..35898	35898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10616.28 Da
• Isoelectric Point: 9.5064

>T206515 WP_053868684.1 NZ_CP076837:30545-30814 [Campylobacter jejuni X]
MPYKITLSKKYKQKYKKANTKDRILIDEVVEKLSNDETLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKNNDILELYLA
NLGNHNNIF

Nucleotide

• Length: 270 bp

>T206515 NZ_CP102472:2517649-2518026 [Burkholderia multivorans]
ATGGGTATAAATTCATCGATGGTTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGGACTTGAAAGCGAT
GCCCGAAGCGGTACGGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGTTTCGGATCGGCCGGCGTACTCGAGGTCGTGGAGTCGGAGCACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGCGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.76 Da
• Isoelectric Point: 10.0400

>AT206515 WP_053868685.1 NZ_CP076837:30271-30555 [Campylobacter jejuni X]
MFDYSKYENASKKQLIHALTLAEKRAEKLNSQLKENNEFFKFLQKKLKKSFNAKKTKKAEQRRPELDEAIEDYKNGNVET
YANFEEYKKAMNAL

Nucleotide

• Length: 285 bp

>AT206515 NZ_CP102472:2518026-2518349 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGGAACGTCTACGCGGATCTTGGCACGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGACTCGCAAATGGACGCAGCAGCACGCAGCACGATTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Structures

Antitoxin

• AlphaFold DB: A0A5T1CFM5