Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 2521..3122 Replicon plasmid LP2025_8
Accession NZ_CP076832
Organism Lactiplantibacillus plantarum 2025

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag N876_RS16540 Protein ID WP_001748110.1
Coordinates 2778..3122 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag N876_RS16535 Protein ID WP_003643337.1
Coordinates 2521..2784 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N876_RS16520 (N876_16520) 60..473 - 414 WP_021357813.1 replication initiation protein -
N876_RS16525 (N876_16525) 1476..1565 - 90 Protein_1 IS30 family transposase -
N876_RS16530 (N876_16530) 1848..2435 - 588 WP_003646144.1 site-specific integrase -
N876_RS16535 (N876_16535) 2521..2784 + 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N876_RS16540 (N876_16540) 2778..3122 + 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N876_RS16545 (N876_16545) 3441..3914 + 474 WP_031263960.1 ThiF family adenylyltransferase -
N876_RS16550 (N876_16550) 3995..5290 + 1296 WP_031263959.1 MFS transporter -
N876_RS16555 (N876_16555) 5416..5712 - 297 WP_054519405.1 DUF5839 family protein -
N876_RS16560 (N876_16560) 5789..6097 - 309 WP_217078732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11537 11537
- flank IS/Tn - - 3371..3469 98


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T206514 WP_001748110.1 NZ_CP076832:2778-3122 [Lactiplantibacillus plantarum 2025]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

>T206514 NZ_CP102472:152863-153264 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTGGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGGGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGTGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACCACGAGCGTGATTTCGCGGGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGGTCGGCT
AG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.51 Da        Isoelectric Point: 6.4708

>AT206514 WP_003643337.1 NZ_CP076832:2521-2784 [Lactiplantibacillus plantarum 2025]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp

>AT206514 NZ_CP102472:152627-152863 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References