Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3616239..3616900 Replicon chromosome
Accession NC_003047
Organism Sinorhizobium meliloti 1021

Toxin (Protein)


Gene name vapC Uniprot ID Q92KY5
Locus tag SM_RS16980 Protein ID WP_010970565.1
Coordinates 3616239..3616643 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92KY4
Locus tag SM_RS16985 Protein ID WP_010970566.1
Coordinates 3616640..3616900 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM_RS16965 (SMc04405) 3611782..3612894 + 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -
SM_RS16970 (SMc04406) 3613023..3613730 + 708 WP_010970563.1 phosphatase PAP2 family protein -
SM_RS16975 (SMc04407) 3613831..3615720 - 1890 WP_010970564.1 MHS family MFS transporter -
SM_RS16980 (SMc04881) 3616239..3616643 - 405 WP_010970565.1 type II toxin-antitoxin system VapC family toxin Toxin
SM_RS16985 (SMc04408) 3616640..3616900 - 261 WP_010970566.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SM_RS31645 (SMc04409) 3617029..3617199 + 171 WP_010970567.1 hypothetical protein -
SM_RS16990 (SMc04410) 3617313..3618347 + 1035 WP_003531790.1 aspartate-semialdehyde dehydrogenase -
SM_RS16995 (SMc04411) 3618520..3619341 + 822 WP_010970568.1 lytic transglycosylase family protein -
SM_RS17000 (SMc04083) 3619688..3620371 - 684 WP_010970569.1 carbonic anhydrase -
SM_RS17005 (SMc04084) 3620545..3621426 - 882 WP_010970570.1 pyridoxal kinase PdxY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14507.71 Da        Isoelectric Point: 6.7257

>T20651 WP_010970565.1 NC_003047:c3616643-3616239 [Sinorhizobium meliloti 1021]
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

>T20651 NC_003047:c3616643-3616239 [Sinorhizobium meliloti 1021]
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9903.16 Da        Isoelectric Point: 5.1253

>AT20651 WP_010970566.1 NC_003047:c3616900-3616640 [Sinorhizobium meliloti 1021]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR

Download         Length: 261 bp

>AT20651 NC_003047:c3616900-3616640 [Sinorhizobium meliloti 1021]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92KY5

Antitoxin

Source ID Structure
AlphaFold DB Q92KY4

References