Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2094919..2095433 Replicon chromosome
Accession NZ_CP076823
Organism Staphylococcus aureus strain ST59

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KQY23_RS10235 Protein ID WP_000581792.1
Coordinates 2094919..2095128 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KQY23_RS10240 Protein ID WP_000138934.1
Coordinates 2095140..2095433 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQY23_RS10215 (2090427) 2090427..2091785 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KQY23_RS10220 (2091800) 2091800..2092870 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KQY23_RS10225 (2093188) 2093188..2094390 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KQY23_RS10230 (2094654) 2094654..2094791 - 138 WP_000828354.1 Lmo0850 family protein -
KQY23_RS10235 (2094919) 2094919..2095128 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KQY23_RS10240 (2095140) 2095140..2095433 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KQY23_RS10245 (2095599) 2095599..2097083 + 1485 WP_057504585.1 cardiolipin synthase -
KQY23_RS10250 (2097111) 2097111..2097758 + 648 WP_001187610.1 HD domain-containing protein -
KQY23_RS10255 (2098573) 2098573..2099445 - 873 WP_000725802.1 membrane protein insertase YidC -
KQY23_RS10260 (2099531) 2099531..2100172 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T206507 WP_000581792.1 NZ_CP076823:c2095128-2094919 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T206507 NZ_CP102463:c2105194-2104877 [Burkholderia contaminans]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACACCTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTTTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCGCCGG
TCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGTGGCGATAAATCGTCGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT206507 WP_000138934.1 NZ_CP076823:c2095433-2095140 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT206507 NZ_CP102463:c2104873-2104574 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References