Detailed information of TA system TA206506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2075179..2075708
• Replicon: chromosome
• Accession: NZ_CP076823
• Organism: Staphylococcus aureus strain ST59

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KQY23_RS10145
• Protein ID: WP_000621175.1
• Coordinates: 2075179..2075541 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: KQY23_RS10150
• Protein ID: WP_000948331.1
• Coordinates: 2075538..2075708 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY23_RS10125 (2072158)	2072158..2072928	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
KQY23_RS10130 (2072903)	2072903..2073382	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
KQY23_RS10135 (2073384)	2073384..2073710	-	327	WP_001052491.1	anti-sigma factor antagonist	-
KQY23_RS10140 (2073829)	2073829..2074830	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
KQY23_RS10145 (2075179)	2075179..2075541	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KQY23_RS10150 (2075538)	2075538..2075708	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
KQY23_RS10155 (2075793)	2075793..2076941	-	1149	WP_001280702.1	alanine racemase	-
KQY23_RS10160 (2077007)	2077007..2077366	-	360	WP_000581194.1	holo-ACP synthase	-
KQY23_RS10165 (2077370)	2077370..2077861	-	492	WP_001205915.1	PH domain-containing protein	-
KQY23_RS10170 (2077848)	2077848..2079431	-	1584	WP_001294642.1	PH domain-containing protein	-
KQY23_RS10175 (2079424)	2079424..2079903	-	480	WP_001287083.1	hypothetical protein	-
KQY23_RS10180 (2080112)	2080112..2080672	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T206506 WP_000621175.1 NZ_CP076823:c2075541-2075179 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T206506 NZ_CP102463:c2104873-2104574 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT206506 WP_000948331.1 NZ_CP076823:c2075708-2075538 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT206506 NZ_CP102463:c2105194-2104877 [Burkholderia contaminans]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACACCTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTTTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCGCCGG
TCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGTGGCGATAAATCGTCGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1