Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1922913..1923689 Replicon chromosome
Accession NZ_CP076823
Organism Staphylococcus aureus strain ST59

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KQY23_RS09260 Protein ID WP_000031108.1
Coordinates 1922913..1923065 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag KQY23_RS09265 Protein ID WP_001251218.1
Coordinates 1923090..1923689 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQY23_RS09245 (1918988) 1918988..1919809 + 822 WP_000669384.1 RluA family pseudouridine synthase -
KQY23_RS09250 (1920274) 1920274..1921659 - 1386 WP_000116233.1 class II fumarate hydratase -
KQY23_RS09255 (1921855) 1921855..1922250 - 396 WP_057504578.1 hypothetical protein -
KQY23_RS09260 (1922913) 1922913..1923065 - 153 WP_000031108.1 SAS053 family protein Toxin
KQY23_RS09265 (1923090) 1923090..1923689 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
KQY23_RS09270 (1923848) 1923848..1924318 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KQY23_RS09275 (1924323) 1924323..1925450 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
KQY23_RS09280 (1925601) 1925601..1926323 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KQY23_RS09285 (1926316) 1926316..1927773 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T206505 WP_000031108.1 NZ_CP076823:c1923065-1922913 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T206505 NZ_CP102463:c306359-305940 [Burkholderia contaminans]
ATGATCCTTGTTGATACGAACGTGATGTCCGAGCCGCTGCGGCGTGAGCCGAGCACGGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAAACGCTGTTTCTTGCTGCGATCAGTCTTGGCGAAATGCGCTTCGGCGTGGCGGCACTCCCGGAAGGGC
GCAGGCGCGACTGGCTTCACCACGGCATCGAGCAACGCGTCGTGCCGCTGTTTCGCGGCAGGATTCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCATTCGAGCGCGTGCGCGTGCCTCGGGCAGTGCGATCGCGCCTGCCGATGTCTTTAT
TGCCGCGACGGCCGAGGCGAACGGATTGATCATTGCGACGCGCGATGGTGCGCCATTCGAGGCTGTCGGCCTGCGGGTGA
TTGATCCATGGGCGTCGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT206505 WP_001251218.1 NZ_CP076823:c1923689-1923090 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT206505 NZ_CP102463:c306595-306356 [Burkholderia contaminans]
ATGCCCGTGATTACCGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTCCGAGTCCGTGCGGCGCAGCATGGGCGTAG
CACCGAAGCCGAGGTGCGTGACATCCTCGAGCAGGCCGTTCTGCCGGGCGGCCGGCTGAAGCTGGGAACGCTGCTGGCGG
AAATCGGACGGGAGGCGGGCGGCGTCGAATTCGACGTTCGGCGCGACAAGACGCTAACCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References