Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 851218..851750 Replicon chromosome
Accession NZ_CP076823
Organism Staphylococcus aureus strain ST59

Toxin (Protein)


Gene name TscT Uniprot ID Q93CD4
Locus tag KQY23_RS04035 Protein ID WP_001103942.1
Coordinates 851430..851750 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag KQY23_RS04030 Protein ID WP_001058486.1
Coordinates 851218..851427 (+) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQY23_RS03985 (846236) 846236..847456 - 1221 WP_000266157.1 site-specific integrase -
KQY23_RS03990 (847545) 847545..848273 - 729 WP_000733774.1 staphylococcal enterotoxin type K -
KQY23_RS03995 (848297) 848297..849025 - 729 WP_001033316.1 staphylococcal enterotoxin type Q -
KQY23_RS04000 (849096) 849096..849527 - 432 WP_001228759.1 hypothetical protein -
KQY23_RS04005 (849544) 849544..850002 - 459 WP_000281657.1 ImmA/IrrE family metallo-endopeptidase -
KQY23_RS04010 (850014) 850014..850346 - 333 WP_001260004.1 helix-turn-helix transcriptional regulator -
KQY23_RS04015 (850539) 850539..850802 + 264 WP_000243851.1 helix-turn-helix transcriptional regulator -
KQY23_RS04020 (850795) 850795..851067 + 273 WP_000091731.1 helix-turn-helix domain-containing protein -
KQY23_RS04025 (851079) 851079..851225 + 147 WP_000784875.1 hypothetical protein -
KQY23_RS04030 (851218) 851218..851427 + 210 WP_001058486.1 hypothetical protein Antitoxin
KQY23_RS04035 (851430) 851430..851750 + 321 WP_001103942.1 DUF1474 family protein Toxin
KQY23_RS04040 (851814) 851814..852683 + 870 WP_216753101.1 primase alpha helix C-terminal domain-containing protein -
KQY23_RS04045 (852700) 852700..854169 + 1470 WP_000390454.1 virulence-associated E family protein -
KQY23_RS04050 (854455) 854455..854817 + 363 WP_001039168.1 hypothetical protein -
KQY23_RS04055 (854819) 854819..855103 + 285 WP_000998181.1 hypothetical protein -
KQY23_RS04060 (855100) 855100..855741 + 642 WP_001019764.1 hypothetical protein -
KQY23_RS04065 (856258) 856258..856599 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 846236..861550 15314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-98)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12694.22 Da        Isoelectric Point: 4.7419

>T206501 WP_001103942.1 NZ_CP076823:851430-851750 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

>T206501 NZ_CP102462:190032-190433 [Burkholderia contaminans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGGTTTGC
GCAGTGCTACACGGGGGACGTCGTAATGTCGGCGATCACGTACGCCGAGCTCGAGTACGGTGTCGCGGCGTGCGCGAGCC
CTGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGACATTCCCGTTGCGCCGTTCGACGTCGCGGCCGCGCAAGCG
TATGGCCCGGTCCGCGAGGCAACCCGGGAGCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTACTCGTGACCAACAACGAGCGGGATTTCGTGAGCTATCCGGGACTGCGGCTGGAGAACTGGCTGGACGATT
GA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT206501 WP_001058486.1 NZ_CP076823:851218-851427 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT206501 NZ_CP102462:189796-190032 [Burkholderia contaminans]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTTGCCTATGAACGCAGCGA
TATCGAACTGGAAATCGAGCGCATTGGTGACGAAATCCGCATTCGGCCGGCGCGGCGGCCGTTGACCCGCGTCCTTGAGA
AATTCGCTAAATTCGGGCCGGATTTCATGGCGGATGGGCGCGGTGACCACGAGCAGGCCGATCGCGAGGGTTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q93CD4


Antitoxin

Source ID Structure

References