206500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 833521..833998 Replicon chromosome
Accession NZ_CP076823
Organism Staphylococcus aureus strain ST59

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KQY23_RS03890 Protein ID WP_000052076.1
Coordinates 833521..833709 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KQY23_RS03895 Protein ID WP_001059690.1
Coordinates 833738..833998 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQY23_RS03860 (829559) 829559..830029 + 471 WP_000824462.1 hypothetical protein -
KQY23_RS03865 (830370) 830370..831056 + 687 WP_001823812.1 thermonuclease family protein -
KQY23_RS03870 (831413) 831413..831613 + 201 WP_001059082.1 cold-shock protein -
KQY23_RS03875 (832112) 832112..832330 - 219 WP_000005888.1 hypothetical protein -
KQY23_RS03880 (832392) 832392..832676 - 285 WP_001004397.1 hypothetical protein -
KQY23_RS03885 (832764) 832764..833333 - 570 WP_001106657.1 lipoprotein N-acylation protein LnsA -
KQY23_RS03890 (833521) 833521..833709 - 189 WP_000052076.1 hypothetical protein Toxin
KQY23_RS03895 (833738) 833738..833998 - 261 WP_001059690.1 hypothetical protein Antitoxin
KQY23_RS03900 (834339) 834339..834542 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KQY23_RS03905 (834539) 834539..834775 - 237 WP_000368687.1 hypothetical protein -
KQY23_RS03910 (835000) 835000..835581 + 582 WP_001140697.1 histidine phosphatase family protein -
KQY23_RS03915 (835654) 835654..836271 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
KQY23_RS03920 (836427) 836427..836921 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
KQY23_RS03925 (837320) 837320..837742 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
KQY23_RS03930 (837890) 837890..838606 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T206500 WP_000052076.1 NZ_CP076823:c833709-833521 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T206500 NZ_CP102459:2193368-2193667 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGTCTTACACGTACGA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTCAGCGCGGCGTTCAAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT206500 WP_001059690.1 NZ_CP076823:c833998-833738 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT206500 NZ_CP102459:2193133-2193378 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References