Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 4050606..4051259 Replicon chromosome
Accession NZ_CP076821
Organism Acinetobacter baumannii strain UC22850

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag KQ255_RS19895 Protein ID WP_000931890.1
Coordinates 4050606..4050995 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KQ255_RS19900 Protein ID WP_001288210.1
Coordinates 4051002..4051259 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ255_RS19880 (KQ255_19780) 4045724..4047919 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
KQ255_RS19885 (KQ255_19785) 4048107..4048673 - 567 WP_000651536.1 rhombosortase -
KQ255_RS19890 (KQ255_19790) 4048751..4049836 - 1086 WP_000049106.1 hypothetical protein -
KQ255_RS19895 (KQ255_19795) 4050606..4050995 - 390 WP_000931890.1 membrane protein Toxin
KQ255_RS19900 (KQ255_19800) 4051002..4051259 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KQ255_RS19905 (KQ255_19805) 4051447..4052619 + 1173 WP_033107737.1 acyl-CoA dehydrogenase family protein -
KQ255_RS19910 (KQ255_19810) 4052669..4054159 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
KQ255_RS19915 (KQ255_19815) 4054340..4054717 - 378 WP_001216380.1 50S ribosomal protein L17 -
KQ255_RS19920 (KQ255_19820) 4054736..4055743 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T206498 WP_000931890.1 NZ_CP076821:c4050995-4050606 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T206498 NZ_CP102459:c370328-369873 [Burkholderia multivorans]
ATGATCCTTGTTGATACGAACGTCATTGCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCTGAAGGGC
GCCGGCGGGACTGGCTCGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAC
GCCGCGAGCAAGGCCTATGCGCGCATTCGCGCGCACGCCCGTGCCGGCGGCAACGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCATTCGAGGCCGCGGGCCTGCGCGTGA
TCGACCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT206498 WP_001288210.1 NZ_CP076821:c4051259-4051002 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT206498 NZ_CP102459:c370564-370325 [Burkholderia multivorans]
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCAGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGTGTGAAGCTCGGAACCTTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGATAAGACGCCAGCCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References