Detailed information of TA system TA206495

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1713312..1713965
• Replicon: chromosome
• Accession: NZ_CP076817
• Organism: Acinetobacter baumannii strain UC24137

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KQ257_RS08235
• Protein ID: WP_046693176.1
• Coordinates: 1713312..1713701 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KQ257_RS08240
• Protein ID: WP_001288210.1
• Coordinates: 1713708..1713965 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ257_RS08220 (KQ257_08190)	1708430..1710625	-	2196	WP_001158911.1	TRAP transporter large permease subunit	-
KQ257_RS08225 (KQ257_08195)	1710813..1711379	-	567	WP_000651536.1	rhombosortase	-
KQ257_RS08230 (KQ257_08200)	1711457..1712542	-	1086	WP_000049106.1	hypothetical protein	-
KQ257_RS08235 (KQ257_08205)	1713312..1713701	-	390	WP_046693176.1	membrane protein	Toxin
KQ257_RS08240 (KQ257_08210)	1713708..1713965	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KQ257_RS08245 (KQ257_08215)	1714153..1715325	+	1173	WP_001190547.1	acyl-CoA dehydrogenase family protein	-
KQ257_RS08250 (KQ257_08220)	1715372..1716862	-	1491	WP_046693177.1	NAD(P)/FAD-dependent oxidoreductase	-
KQ257_RS08255 (KQ257_08225)	1717044..1717421	-	378	WP_001216380.1	50S ribosomal protein L17	-
KQ257_RS08260 (KQ257_08230)	1717440..1718447	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15691.00 Da
• Isoelectric Point: 10.4945

>T206495 WP_046693176.1 NZ_CP076817:c1713701-1713312 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWRKLKTLEKLY

Nucleotide

• Length: 390 bp

>T206495 NZ_CP102458:c2594654-2594349 [Burkholderia multivorans]
ATGACCACAACCGAAGCGATCAAAGTGACGCCCTTTGATGCATCGGAATACCTTGACGACGAAGAAACAATCGCGAGCTA
TATCAGTGCTGCGATGGAAGCAGACGACCAAGATGTTCTTCTTCTGGCTCTCGCTGACGTCGCAAAGGCCAGAGGCATGG
CTAAGGTAGCAGCCGATGCTGGATTGGGCCGGGAAAGCCTTTACAAGGCCCTCAAGCCAGGTGCGAATCCAAAATACGAG
ACCGTCAACAAATTGATGCATGCCCTTGGGATCAAGTTCGCCGCGGTTCCGAATCGAAAGAGTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT206495 WP_001288210.1 NZ_CP076817:c1713965-1713708 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT206495 NZ_CP102458:c2594959-2594651 [Burkholderia multivorans]
ATGAACACGATCAACCAAACAGGCGAGTTCCAGGAGTGGCTCCGCGACCTGAAAGATAAGGTTGGAAGGGGCGCCATCCT
TGGCCGAATCAATCGTGCGCGCTTGGGGAATTTCGGCGATCACAAAGATTTGGGCGATGGTGTTTCAGAGATGCGGATTG
ATGTCGGACCAGGATACCGCGTCTACTTCGGCCGCGATGGCAAGGACATCTACTTGCTCATTTGCGGGGGTGACAAATCC
TCTCAGGACAAGGATATCAAGCACGCCAAGGCGATCTGGGAGCAGTTCAGGAAGGAGCAACAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7