Detailed information of TA system TA206494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 580175..580854
• Replicon: chromosome
• Accession: NZ_CP076817
• Organism: Acinetobacter baumannii strain UC24137

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KQ257_RS02815
• Protein ID: WP_253564065.1
• Coordinates: 580672..580854 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KQ257_RS02810
• Protein ID: WP_000966688.1
• Coordinates: 580175..580579 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ257_RS02790 (KQ257_02775)	578454..578780	-	327	WP_000721696.1	hypothetical protein	-
KQ257_RS02795 (KQ257_02780)	578852..579535	-	684	WP_000720504.1	hypothetical protein	-
KQ257_RS02800 (KQ257_02785)	579567..579890	-	324	WP_000523929.1	DUF4236 domain-containing protein	-
KQ257_RS02805 (KQ257_02790)	579899..580075	-	177	WP_075149899.1	hypothetical protein	-
KQ257_RS02810 (KQ257_02795)	580175..580579	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KQ257_RS02815 (KQ257_02800)	580672..580854	-	183	WP_253564065.1	type II toxin-antitoxin system HicA family toxin	Toxin
KQ257_RS02820 (KQ257_02805)	581180..581695	-	516	WP_001185592.1	hypothetical protein	-
KQ257_RS02825 (KQ257_02810)	581765..582682	-	918	WP_000094273.1	phage tail tube protein	-
KQ257_RS02830 (KQ257_02815)	582735..583706	-	972	WP_046693290.1	hypothetical protein	-
KQ257_RS02835 (KQ257_02820)	583706..584059	-	354	WP_032051762.1	hypothetical protein	-
KQ257_RS02840 (KQ257_02825)	584155..584373	-	219	WP_002002228.1	hypothetical protein	-
KQ257_RS02845 (KQ257_02830)	584375..584773	-	399	WP_002062850.1	phage tail terminator-like protein	-
KQ257_RS02850 (KQ257_02835)	584775..585143	-	369	WP_001993865.1	hypothetical protein	-
KQ257_RS02855 (KQ257_02840)	585115..585519	-	405	WP_000247952.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	555754..618184	62430

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.88 Da
• Isoelectric Point: 10.6602

>T206494 WP_253564065.1 NZ_CP076817:c580854-580672 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKKAGLN

Nucleotide

• Length: 183 bp

>T206494 NZ_CP102458:2563859-2564236 [Burkholderia multivorans]
ATGGGTATAAATTCGTCGATGGTTCCATACACTAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGTTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCGACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCAGCCGAAGCACACGCAAATGGAGGAAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT206494 WP_000966688.1 NZ_CP076817:c580579-580175 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT206494 NZ_CP102458:2564236-2564559 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGACTCGCAAATGGACGCAGCAGCACGCAGCACGATTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Structures

Antitoxin

• AlphaFold DB: N9L2H6